Molecular Dynamics Insights into Polyamine–DNA Binding Modes: Implications for Cross‐Link Selectivity

Biogenic polyamines, which play a role in DNA condensation and stabilization, are ubiquitous and are found at millimolar concentration in the nucleus of eukaryotic cells. The interaction modes of three polyamines—putrescine (Put), spermine (Spm), and spermidine (Spd)—with a self‐complementary 16 bas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry : a European journal 2017-09, Vol.23 (52), p.12845-12852
Hauptverfasser:	Bignon, Emmanuelle, Chan, Chen‐Hui, Morell, Christophe, Monari, Antonio, Ravanat, Jean‐Luc, Dumont, Elise
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Ammonium Analytical chemistry Binding Binding Sites Calorimetry Chemical Sciences Chemistry Correlation analysis cross-coupling Crosslinking Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism Guanine Guanines Heat measurement Molecular dynamics Molecular Dynamics Simulation noncovalent interactions Nuclei Nuclei (cytology) Nucleic Acid Conformation Oxidation Polyamines Polyamines - chemistry Polyamines - metabolism Post-production processing Putrescine Putrescine - chemistry Putrescine - metabolism Selectivity Spermidine Spermidine - chemistry Spermidine - metabolism Spermine Spermine - chemistry Spermine - metabolism Thermodynamics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!