Thermo-resistance based micro-calorimeter for continuous chemical enthalpy measurements

We present a thermo-resistance based micro-calorimeter using a glass/platinum/PDMS prototyping technology which is more flexible than the existing silicon based technology for lab on a chip device integration. Resistance monitoring and fluid injection techniques are optimized in order to reduce thermal noises and improve the detection sensibility. We used neutralization acid-base reaction to evaluate the device capability in determination of both reagent concentration and reaction enthalpy. We also performed a glucose/glucose oxydase enzymatic reaction to illustrate the advantage of using PDMS device for the studies of aerobic reaction.