Increased HIF-1α expression correlates with cell proliferation and vascular markers CD31 and VEGF-A in uveal melanoma

Overexpression of hypoxia inducible factor-1 α (HIF-1α) has been found in several cancers and is thought to correlate with aggressive disease. The purpose of our study was to investigate the influence of HIF-1α on clinical outcome in uveal melanoma (UM) along with proliferative (MIB-1) and vascular...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2014-03, Vol.55 (3), p.1277-1283
Hauptverfasser:	Mouriaux, Frédéric, Sanschagrin, François, Diorio, Caroline, Landreville, Solange, Comoz, François, Petit, Edwige, Bernaudin, Myriam, Rousseau, Alain P, Bergeron, Dan, Morcos, Mohib
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Cell Proliferation Female Humans Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Immunohistochemistry Life Sciences Male Melanoma - metabolism Melanoma - pathology Middle Aged Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Prognosis Retrospective Studies Tissue Array Analysis Uveal Neoplasms - metabolism Uveal Neoplasms - pathology Vascular Endothelial Growth Factor A - metabolism Young Adult
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