Promoter Activation by Enhancer-Dependent and -Independent Loading of Activator and Coactivator Complexes

Activation of the pDβ1 promoter at the TCRβ locus requires a functional distal enhancer, Eβ. Here, we have analyzed the mechanism of promoter activation in thymocytes from mice containing or lacking Eβ. We found that pDβ1 shows a complex profile of transcription factor and chromatin remodeling compl...

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Veröffentlicht in:	Molecular cell 2002-12, Vol.10 (6), p.1479-1487
Hauptverfasser:	Spicuglia, Salvatore, Kumar, Sanjeev, Yeh, Jung-Hua, Vachez, Elodie, Chasson, Lionel, Gorbatch, Sophie, Cautres, Julie, Ferrier, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Binding Sites Chromatin - genetics Chromatin - immunology Chromatin - ultrastructure Chromosome Mapping DNA Footprinting DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Gene Expression Regulation Genes, T-Cell Receptor beta - genetics Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Nucleosomes - genetics Polymerase Chain Reaction Promoter Regions, Genetic
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