Mu and delta opioid receptor knockout mice show increased colonic sensitivity

Background Opiates act through opioid receptors to diminish pain. Here, we investigated whether mu (MOR) and delta (DOR) receptor endogenous activity assessed in the whole mouse body or in particular at peripheral receptors on primary nociceptive neurons, control colonic pain. Methods We compared gl...

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Veröffentlicht in:	European journal of pain 2017-04, Vol.21 (4), p.623-634
Hauptverfasser:	Reiss, D., Ceredig, R.A., Secher, T., Boué, J., Barreau, F., Dietrich, G., Gavériaux‐Ruff, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Colitis - chemically induced Colitis - genetics Colitis - metabolism Dextran Sulfate Dynorphins - genetics Dynorphins - metabolism Enkephalins - genetics Enkephalins - metabolism Female Human health and pathology Hépatology and Gastroenterology Interleukin-1beta - genetics Interleukin-1beta - metabolism Life Sciences Male Mice Mice, Knockout Pain - genetics Pain - metabolism Pain Management Protein Precursors - genetics Protein Precursors - metabolism Receptors, Opioid, delta - genetics Receptors, Opioid, delta - metabolism Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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