Pharmacokinetic–pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida

A calf tissue cage model was used to study the pharmacokinetics (PK) and pharmacodynamics (PD) of oxytetracycline in serum, inflamed (exudate) and noninflamed (transudate) tissue cage fluids. After intramuscular administration, the PK was characterized by a long mean residence time of 28.3 hr. Based...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2018-02, Vol.41 (1), p.28-38
Hauptverfasser:	Lees, P., Potter, T., Pelligand, L., Toutain, P.‐L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Bacterial Load - drug effects Bacterial Load - veterinary calf Cattle Female Injections, Intramuscular - veterinary Life Sciences M. haemolytica Mannheimia haemolytica - drug effects Microbial Sensitivity Tests - veterinary oxytetracycline Oxytetracycline - administration & dosage Oxytetracycline - blood Oxytetracycline - pharmacokinetics Oxytetracycline - pharmacology P. multocida Pasteurella Infections - drug therapy Pasteurella Infections - veterinary Pasteurella multocida - drug effects pharmacodynamics pharmacokinetics Pneumonia of Calves, Enzootic - drug therapy
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