Endogenous polyclonal anti–IL-1 antibody responses potentiate IL-1 activity during pathogenic inflammation

Background Particular neutralizing mAbs to certain cytokines act as agonists in vivo through protection of the cytokine's active site and prolongation of its half-life. Although this principle might be useful for targeted immunotherapy, its role in the pathogenesis of inflammation and autoimmun...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2017-06, Vol.139 (6), p.1957-1965.e3
Hauptverfasser:	Spohn, Gunther, PhD, Arenas-Ramirez, Natalia, PhD, Bouchaud, Gregory, PhD, Boyman, Onur, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal models Animals Antibodies - immunology antibody Arthritis autoantibody Autoimmune diseases autoinflammatory disease Bacterial infections Biological activity Chromatography Cytokine Cytokines Granulocytes HEK293 Cells HeLa Cells Humans IL-1β Immune response Immunoglobulins Immunotherapy Infections Inflammation Inflammation - blood Inflammation - immunology Inflammatory bowel diseases inflammatory disease Inflammatory diseases Interleukin 1 Interleukin-1beta - blood Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-6 - blood Intestine Life Sciences Male Mice, Inbred C57BL Mice, Inbred DBA Mimicry Morbidity Mutagenesis Mutation Neutralizing Prolongation Proteins Rheumatoid arthritis Vaccines Virus-like particles
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