Snail2 and Zeb2 repress P-cadherin to define embryonic territories in the chick embryo

Snail and Zeb transcription factors induce epithelial-to-mesenchymal transition (EMT) in embryonic and adult tissues by direct repression of transcription. The repression of E-cadherin transcription by the EMT inducers Snail1 and Zeb2 plays a fundamental role in defining embryonic territories in the...

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Veröffentlicht in:	Development (Cambridge) 2017-02, Vol.144 (4), p.649-656
Hauptverfasser:	Acloque, Hervé, Ocaña, Oscar H, Abad, Diana, Stern, Claudio D, Nieto, M Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cadherins - metabolism Chick Embryo Chickens Down-Regulation E-cadherin Ectoderm Ectoderm - metabolism Embryogenesis Epithelial-Mesenchymal Transition - genetics Gastrulation Gastrulation - genetics Gene silencing Homeodomain Proteins - genetics Homeodomain Proteins - physiology Life Sciences Mesenchyme Mice Neural plate Neural stem cells Neurons - metabolism Primitive streak Primitive Streak - embryology Promoter Regions, Genetic Repressor Proteins - genetics Repressor Proteins - physiology Snail Family Transcription Factors - genetics Snail Family Transcription Factors - physiology Snail protein Transcription factors
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