Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse

Estrogen receptor α (ERα) regulates gene transcription through two activation functions (ERα-AF1 and ERα-AF2). We recently found that the protection conferred by 17β-estradiol against obesity and insulin resistance requires ERα-AF2 but not ERα-AF1. However, the interplay between the two ERα-AFs is p...

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Veröffentlicht in:	The American journal of pathology 2017-06, Vol.187 (6), p.1273-1287
Hauptverfasser:	Guillaume, Maeva, Handgraaf, Sandra, Fabre, Aurélie, Raymond-Letron, Isabelle, Riant, Elodie, Montagner, Alexandra, Vinel, Alexia, Buscato, Melissa, Smirnova, Natalia, Fontaine, Coralie, Guillou, Hervé, Arnal, Jean-François, Gourdy, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet, High-Fat Drug Evaluation, Preclinical - methods Estrogen Receptor alpha - antagonists & inhibitors Estrogen Receptor alpha - deficiency Estrogen Receptor alpha - genetics Estrogen Receptor alpha - physiology Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - pathology Fatty Liver - prevention & control Female Gene Expression Regulation - drug effects Insulin Resistance - physiology Life Sciences Liver - metabolism Mice, Inbred C57BL Mice, Knockout Obesity - etiology Obesity - metabolism Obesity - prevention & control Ovariectomy Pathology Selective Estrogen Receptor Modulators - pharmacology Selective Estrogen Receptor Modulators - therapeutic use Tamoxifen - pharmacology Tamoxifen - therapeutic use Weight Gain - drug effects
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