Using murine colitis models to analyze probiotics–host interactions
Abstract Probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status a...
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| Veröffentlicht in: | FEMS microbiology reviews 2017-08, Vol.41 (Supp_1), p.S49-S70 |
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| creator | Martín, Rebeca Chain, Florian Miquel, Sylvie Motta, Jean-Paul Vergnolle, Nathalie Sokol, Harry Langella, Philippe |
| description | Abstract
Probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.
Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests. |
| doi_str_mv | 10.1093/femsre/fux035 |
| format | Article |
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Probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.
Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.</description><identifier>ISSN: 1574-6976</identifier><identifier>ISSN: 0168-6445</identifier><identifier>EISSN: 1574-6976</identifier><identifier>DOI: 10.1093/femsre/fux035</identifier><identifier>PMID: 28830096</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animal models ; Animals ; Bifidobacterium - growth & development ; Bifidobacterium - metabolism ; Biocompatibility ; Biomedical materials ; Colitis ; Colitis - chemically induced ; Colitis - therapy ; Disease Models, Animal ; Dysbiosis - microbiology ; Gastrointestinal Microbiome - physiology ; Gastrointestinal tract ; Gastrointestinal Tract - microbiology ; Gastrointestinal Tract - pathology ; Human health and pathology ; Humans ; Hépatology and Gastroenterology ; In vivo methods and tests ; Inflammatory bowel disease ; Lactobacillus - growth & development ; Lactobacillus - metabolism ; Life Sciences ; Mice ; Microorganisms ; Model testing ; Probiotics ; Probiotics - therapeutic use ; Storage conditions ; Strains (organisms)</subject><ispartof>FEMS microbiology reviews, 2017-08, Vol.41 (Supp_1), p.S49-S70</ispartof><rights>FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2017</rights><rights>FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Aug 2017</rights><rights>Copyright</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-d80b98000583afd9ac2c27392951d4b38a081f2a6d1c2c559361b57553e10d9d3</citedby><cites>FETCH-LOGICAL-c427t-d80b98000583afd9ac2c27392951d4b38a081f2a6d1c2c559361b57553e10d9d3</cites><orcidid>0000-0002-5980-4113 ; 0000-0003-1825-6015 ; 0000-0002-2914-1822 ; 0000-0001-8787-3311 ; 0000-0002-9464-0695 ; 0000-0001-5960-4341 ; 0000-0001-8405-5073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1598,27901,27902</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/femsre/fux035$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28830096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01602302$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Martín, Rebeca</creatorcontrib><creatorcontrib>Chain, Florian</creatorcontrib><creatorcontrib>Miquel, Sylvie</creatorcontrib><creatorcontrib>Motta, Jean-Paul</creatorcontrib><creatorcontrib>Vergnolle, Nathalie</creatorcontrib><creatorcontrib>Sokol, Harry</creatorcontrib><creatorcontrib>Langella, Philippe</creatorcontrib><title>Using murine colitis models to analyze probiotics–host interactions</title><title>FEMS microbiology reviews</title><addtitle>FEMS Microbiol Rev</addtitle><description>Abstract
Probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.
Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.</description><subject>Animal models</subject><subject>Animals</subject><subject>Bifidobacterium - growth & development</subject><subject>Bifidobacterium - metabolism</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - therapy</subject><subject>Disease Models, Animal</subject><subject>Dysbiosis - microbiology</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gastrointestinal tract</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Gastrointestinal Tract - pathology</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hépatology and Gastroenterology</subject><subject>In vivo methods and tests</subject><subject>Inflammatory bowel disease</subject><subject>Lactobacillus - growth & development</subject><subject>Lactobacillus - metabolism</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Microorganisms</subject><subject>Model testing</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Storage conditions</subject><subject>Strains (organisms)</subject><issn>1574-6976</issn><issn>0168-6445</issn><issn>1574-6976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkbFOwzAURS0EoiUwsqJILDCEPtuxE49VVShSJRY6W07iUFdJXOIEUSb-gT_kS0iVUhALky376Pr4XYTOMdxgEHSU69LVepS3r0DZARpiFoUBFxE__LUfoBPnVgDABGPHaEDimAIIPkTThTPVk1-2tam0n9rCNMb5pc104fzG-qpSxeZN--vaJsY2JnWf7x9L6xrfVI2uVdoYW7lTdJSrwumz3eqhxe30cTIL5g9395PxPEhDEjVBFkMi4q1GTFWeCZWSlERUEMFwFiY0VhDjnCie4e6GMUE5TljEGNUYMpFRD133uUtVyHVtSlVvpFVGzsZzuT0DzIFQIC-4Y696tlN_brVrZGlcqotCVdq2TmJBcYQ57l7x0OUfdGXbuvu5kwQg5JHgnaaHgp5Ka-u6med7Awxy24Xsu5B9Fx1_sUttk1Jne_p7-D-Gtl3_k_UFlCGUBQ</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Martín, Rebeca</creator><creator>Chain, Florian</creator><creator>Miquel, Sylvie</creator><creator>Motta, Jean-Paul</creator><creator>Vergnolle, Nathalie</creator><creator>Sokol, Harry</creator><creator>Langella, Philippe</creator><general>Oxford University Press</general><general>Wiley-Blackwell</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5980-4113</orcidid><orcidid>https://orcid.org/0000-0003-1825-6015</orcidid><orcidid>https://orcid.org/0000-0002-2914-1822</orcidid><orcidid>https://orcid.org/0000-0001-8787-3311</orcidid><orcidid>https://orcid.org/0000-0002-9464-0695</orcidid><orcidid>https://orcid.org/0000-0001-5960-4341</orcidid><orcidid>https://orcid.org/0000-0001-8405-5073</orcidid></search><sort><creationdate>20170801</creationdate><title>Using murine colitis models to analyze probiotics–host interactions</title><author>Martín, Rebeca ; Chain, Florian ; Miquel, Sylvie ; Motta, Jean-Paul ; Vergnolle, Nathalie ; Sokol, Harry ; Langella, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-d80b98000583afd9ac2c27392951d4b38a081f2a6d1c2c559361b57553e10d9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Bifidobacterium - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>FEMS microbiology reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Martín, Rebeca</au><au>Chain, Florian</au><au>Miquel, Sylvie</au><au>Motta, Jean-Paul</au><au>Vergnolle, Nathalie</au><au>Sokol, Harry</au><au>Langella, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using murine colitis models to analyze probiotics–host interactions</atitle><jtitle>FEMS microbiology reviews</jtitle><addtitle>FEMS Microbiol Rev</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>41</volume><issue>Supp_1</issue><spage>S49</spage><epage>S70</epage><pages>S49-S70</pages><issn>1574-6976</issn><issn>0168-6445</issn><eissn>1574-6976</eissn><abstract>Abstract
Probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.
Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28830096</pmid><doi>10.1093/femsre/fux035</doi><orcidid>https://orcid.org/0000-0002-5980-4113</orcidid><orcidid>https://orcid.org/0000-0003-1825-6015</orcidid><orcidid>https://orcid.org/0000-0002-2914-1822</orcidid><orcidid>https://orcid.org/0000-0001-8787-3311</orcidid><orcidid>https://orcid.org/0000-0002-9464-0695</orcidid><orcidid>https://orcid.org/0000-0001-5960-4341</orcidid><orcidid>https://orcid.org/0000-0001-8405-5073</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | FEMS microbiology reviews, 2017-08, Vol.41 (Supp_1), p.S49-S70 |
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| source | Oxford Journals Open Access Collection |
| subjects | Animal models Animals Bifidobacterium - growth & development Bifidobacterium - metabolism Biocompatibility Biomedical materials Colitis Colitis - chemically induced Colitis - therapy Disease Models, Animal Dysbiosis - microbiology Gastrointestinal Microbiome - physiology Gastrointestinal tract Gastrointestinal Tract - microbiology Gastrointestinal Tract - pathology Human health and pathology Humans Hépatology and Gastroenterology In vivo methods and tests Inflammatory bowel disease Lactobacillus - growth & development Lactobacillus - metabolism Life Sciences Mice Microorganisms Model testing Probiotics Probiotics - therapeutic use Storage conditions Strains (organisms) |
| title | Using murine colitis models to analyze probiotics–host interactions |
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