Complementary Roles of Nod2 in Hematopoietic and Nonhematopoietic Cells in Preventing Gut Barrier Dysfunction Dependent on MLCK Activity

Crohn's disease (CD) pathogenesis is multifactorial involving genetic and environmental factors. Loss of function mutations in the nucleotide oligomerization domain 2 (NOD2) gene are the main genetic risk factor for CD. Like patients with CD, Nod2 mice are characterized by an enhanced Th1 immun...

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Veröffentlicht in:	Inflammatory bowel diseases 2017-07, Vol.23 (7), p.1109-1119
Hauptverfasser:	Al Nabhani, Ziad, Montcuquet, Nicolas, Roy, Maryline, Dussaillant, Monique, Hugot, Jean-Pierre, Barreau, Frédérick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caco-2 Cells Cell Membrane Permeability Hematopoietic Stem Cells - metabolism Human health and pathology Humans Hépatology and Gastroenterology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Myosin-Light-Chain Kinase - metabolism Nod2 Signaling Adaptor Protein - physiology Peyer's Patches - metabolism Phosphorylation Tight Junctions
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