Role of ABC transporters in trans‐epithelial transport of vitamin K antagonists

Vitamin K antagonists (VKAs) remain the oral anticoagulant of choice in venous thromboembolic disease. These drugs are characterized by a large inter‐individual variability requiring frequent dose tailoring. Genetic polymorphisms for cytochrome CYP2C9 and VKORC1 explain some of the variability, espe...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2017-01, Vol.38 (1), p.20-32
Hauptverfasser:	Espana, Bernadette, Couturier, Solange, Prouillac, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Animals ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics Biological Transport Caco-2 Cells Caco‐2 Dogs Humans intestinal Life Sciences Madin Darby Canine Kidney Cells Vitamin K - antagonists & inhibitors vitamin K antagonists
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