Circulating Klotho Associates With Cardiovascular Morbidity and Mortality During Hemodialysis

Abstract Background Klotho gene was identified as an aging suppressor. In animals, klotho overexpression extends life span, and defective klotho results in rapid aging and early death. The kidney is the main contributor to circulating klotho levels, and, during chronic kidney disease, renal klotho g...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2017-09, Vol.102 (9), p.3154-3161
Hauptverfasser:	Marçais, Christophe, Maucort-Boulch, Delphine, Drai, Jocelyne, Dantony, Emmanuelle, Carlier, Marie-Christine, Blond, Emilie, Genet, Leslie, Kuentz, François, Lataillade, Dominique, Legrand, Eric, Moreau-Gaudry, Xavier, Jean, Guillaume, Fouque, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Biomarkers - blood Calcium Calcium phosphates Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Cardiovascular Diseases - therapy Cohort Studies Confidence Intervals Conservation Diabetes mellitus Female Fibroblast growth factors Fibroblasts Gene expression Glucuronidase - blood Growth factors Heart diseases Hemodialysis Hemoglobin Humans Kidney diseases Kidney transplantation Klotho protein Life Sciences Life span Logistic Models Male Middle Aged Morbidity Mortality Phosphates Prognosis Proportional Hazards Models Prospective Studies Renal Dialysis - methods Renal Dialysis - mortality Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - mortality Renal Insufficiency, Chronic - therapy Risk Assessment Survival Rate Treatment Outcome
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