Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone

We have previously shown that malignant plasma cells expressed the specific receptor for 1,25-dihydroxyvitamin D3 and that this derivative could significantly inhibit the proliferation of such malignant cells. More recently, new vitamin D3 derivatives have been generated with extraordinarily potent...

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Veröffentlicht in:	Blood 1996-12, Vol.88 (12), p.4659-4666
Hauptverfasser:	PUTHIER, D, BATAILLE, R, BARILLE, S, MELLERIN, M.-P, HAROUSSEAU, J.-L, PONZIO, A, ROBILLARD, N, WIJDENES, J, AMIOT, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - drug effects Antigens, CD - physiology Antineoplastic agents Antineoplastic Agents - therapeutic use Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Bioinformatics Biological and medical sciences Calcitriol - analogs & derivatives Calcitriol - pharmacology Calcitriol - therapeutic use Cell Division - drug effects Computer Science Dexamethasone - pharmacology Dexamethasone - therapeutic use Drug Synergism General aspects Humans Interleukin-6 - biosynthesis Medical sciences Multiple Myeloma - pathology Pharmacology. Drug treatments Receptors, Interleukin - drug effects Receptors, Interleukin - physiology Receptors, Interleukin-6 Stromal Cells - metabolism
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