Correlative Analysis of Vertebral Trabecular Bone Microarchitecture and Mechanical Properties: A Combined Ultra-high Field (7 Tesla) MRI and Biomechanical Investigation
STUDY DESIGN.High-resolution imaging and biomechanical investigation of ex-vivo vertebrae. OBJECTIVE.The aim of this study was to assess bone microarchitecture of cadaveric vertebrae using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI) and to determine whether the corresponding micr...
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| creator | Guenoun, Daphne Fouré, Alexandre Pithioux, Martine Guis, Sandrine Le Corroller, Thomas Mattei, Jean-Pierre Pauly, Vanessa Guye, Maxime Bernard, Monique Chabrand, Patrick Champsaur, Pierre Bendahan, David |
| description | STUDY DESIGN.High-resolution imaging and biomechanical investigation of ex-vivo vertebrae.
OBJECTIVE.The aim of this study was to assess bone microarchitecture of cadaveric vertebrae using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI) and to determine whether the corresponding microarchitecture parameters were related to bone mineral density (BMD) and bone strength assessed by dual-energy x-ray absorptiometry (DXA) and mechanical compression tests.
SUMMARY OF BACKGROUND DATA.Limitations of DXA for the assessment of bone fragility and osteoporosis have been recognized and criteria of microarchitecture alteration have been included in the definition of osteoporosis. Although vertebral fracture is the most common osteoporotic fracture, no study has assessed directly vertebral trabecular bone microarchitecture.
METHODS.BMD of 24 vertebrae (L2, L3, L4) from eight cadavers was investigated using DXA. The bone volume fraction (BVF), trabecular thickness (Tb.Th), and trabecular spacing (Tb.Sp) of each vertebra were quantified using UHF MRI. Measurements were performed by two operators to characterize the inter-rater reliability. The whole set of specimens underwent mechanical compression tests to failure and the corresponding failure stress was calculated.
RESULTS.The inter-rater reliability for bone microarchitecture parameters was good with intraclass correlation coefficients ranging from 0.82 to 0.94. Failure load and stress were significantly correlated with BVF, Tb.Sp, and BMD (P |
| doi_str_mv | 10.1097/BRS.0000000000002163 |
| format | Article |
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OBJECTIVE.The aim of this study was to assess bone microarchitecture of cadaveric vertebrae using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI) and to determine whether the corresponding microarchitecture parameters were related to bone mineral density (BMD) and bone strength assessed by dual-energy x-ray absorptiometry (DXA) and mechanical compression tests.
SUMMARY OF BACKGROUND DATA.Limitations of DXA for the assessment of bone fragility and osteoporosis have been recognized and criteria of microarchitecture alteration have been included in the definition of osteoporosis. Although vertebral fracture is the most common osteoporotic fracture, no study has assessed directly vertebral trabecular bone microarchitecture.
METHODS.BMD of 24 vertebrae (L2, L3, L4) from eight cadavers was investigated using DXA. The bone volume fraction (BVF), trabecular thickness (Tb.Th), and trabecular spacing (Tb.Sp) of each vertebra were quantified using UHF MRI. Measurements were performed by two operators to characterize the inter-rater reliability. The whole set of specimens underwent mechanical compression tests to failure and the corresponding failure stress was calculated.
RESULTS.The inter-rater reliability for bone microarchitecture parameters was good with intraclass correlation coefficients ranging from 0.82 to 0.94. Failure load and stress were significantly correlated with BVF, Tb.Sp, and BMD (P < 0.05). Tb.Th was only correlated with the failure stress (P < 0.05). Multiple regression analysis demonstrated that the combination of BVF and BMD improved the prediction of the failure stress from an adjusted R = 0.384 for BMD alone to an adjusted R = 0.414.
CONCLUSION.We demonstrated for the first time that the vertebral bone microarchitecture assessed with UHF MRI was significantly correlated with biomechanical parameters. Our data suggest that the multimodal assessment of BMD and trabecular bone microarchitecture with UHF MRI provides additional information on the risk of vertebral bone fracture and might be of interest for the future investigation of selected osteoporotic patients.Level of EvidenceN /A</description><identifier>ISSN: 0362-2436</identifier><identifier>ISSN: 1529-9430</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/BRS.0000000000002163</identifier><identifier>PMID: 28338579</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Absorptiometry, Photon - methods ; Aged ; Aged, 80 and over ; Biomechanical Phenomena - physiology ; Bone Density - physiology ; Cadaver ; Cancellous Bone - diagnostic imaging ; Female ; Humans ; Life Sciences ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - pathology ; Lumbar Vertebrae - physiology ; Magnetic Resonance Imaging - methods ; Male ; Regression Analysis ; Reproducibility of Results ; Stress, Mechanical</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2017-10, Vol.42 (20), p.E1165-E1172</ispartof><rights>Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3843-a3da4047c909f62bda23fd63f08c1a31a5dcfa4e2bde54ffedce18b5c6e50b03</cites><orcidid>0000-0003-1023-1526 ; 0000-0002-1502-0958 ; 0000-0002-8180-9973 ; 0000-0001-5283-3504</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28338579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01593111$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Guenoun, Daphne</creatorcontrib><creatorcontrib>Fouré, Alexandre</creatorcontrib><creatorcontrib>Pithioux, Martine</creatorcontrib><creatorcontrib>Guis, Sandrine</creatorcontrib><creatorcontrib>Le Corroller, Thomas</creatorcontrib><creatorcontrib>Mattei, Jean-Pierre</creatorcontrib><creatorcontrib>Pauly, Vanessa</creatorcontrib><creatorcontrib>Guye, Maxime</creatorcontrib><creatorcontrib>Bernard, Monique</creatorcontrib><creatorcontrib>Chabrand, Patrick</creatorcontrib><creatorcontrib>Champsaur, Pierre</creatorcontrib><creatorcontrib>Bendahan, David</creatorcontrib><title>Correlative Analysis of Vertebral Trabecular Bone Microarchitecture and Mechanical Properties: A Combined Ultra-high Field (7 Tesla) MRI and Biomechanical Investigation</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>STUDY DESIGN.High-resolution imaging and biomechanical investigation of ex-vivo vertebrae.
OBJECTIVE.The aim of this study was to assess bone microarchitecture of cadaveric vertebrae using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI) and to determine whether the corresponding microarchitecture parameters were related to bone mineral density (BMD) and bone strength assessed by dual-energy x-ray absorptiometry (DXA) and mechanical compression tests.
SUMMARY OF BACKGROUND DATA.Limitations of DXA for the assessment of bone fragility and osteoporosis have been recognized and criteria of microarchitecture alteration have been included in the definition of osteoporosis. Although vertebral fracture is the most common osteoporotic fracture, no study has assessed directly vertebral trabecular bone microarchitecture.
METHODS.BMD of 24 vertebrae (L2, L3, L4) from eight cadavers was investigated using DXA. The bone volume fraction (BVF), trabecular thickness (Tb.Th), and trabecular spacing (Tb.Sp) of each vertebra were quantified using UHF MRI. Measurements were performed by two operators to characterize the inter-rater reliability. The whole set of specimens underwent mechanical compression tests to failure and the corresponding failure stress was calculated.
RESULTS.The inter-rater reliability for bone microarchitecture parameters was good with intraclass correlation coefficients ranging from 0.82 to 0.94. Failure load and stress were significantly correlated with BVF, Tb.Sp, and BMD (P < 0.05). Tb.Th was only correlated with the failure stress (P < 0.05). Multiple regression analysis demonstrated that the combination of BVF and BMD improved the prediction of the failure stress from an adjusted R = 0.384 for BMD alone to an adjusted R = 0.414.
CONCLUSION.We demonstrated for the first time that the vertebral bone microarchitecture assessed with UHF MRI was significantly correlated with biomechanical parameters. Our data suggest that the multimodal assessment of BMD and trabecular bone microarchitecture with UHF MRI provides additional information on the risk of vertebral bone fracture and might be of interest for the future investigation of selected osteoporotic patients.Level of EvidenceN /A</description><subject>Absorptiometry, Photon - methods</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomechanical Phenomena - physiology</subject><subject>Bone Density - physiology</subject><subject>Cadaver</subject><subject>Cancellous Bone - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Lumbar Vertebrae - physiology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Stress, Mechanical</subject><issn>0362-2436</issn><issn>1529-9430</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1uEzEUhS1ERUPhDRDysl1MsceeP3ZJRGmkRKAS2Fp3PHc6Bmec2jOp-kY8Jk7TFsQCvLFkf-f4-p5LyBvOzjmrinezqy_n7I-V8lw8IxOepWXCeVY9JxMm8jRJpciPycsQvkcoF7x6QY7TUogyK6oJ-Tl33qOFweyQTnuwd8EE6lr6Df2AtQdL1x5q1KMFT2euR7oy2jvwujMD6mH0SKFv6Ap1B73RUfDZu21UGwzv6ZTO3aY2PTb0qx08JJ257uiFQdvQ04KuMVg4o6urxb3JzLjNb59Fv8MwmOtYnOtfkaMWbMDXD_sJWV98WM8vk-Wnj4v5dJloUUqRgGhAMlnoilVtntYNpKJtctGyUnMQHLJGtyAx3mAm2xYbjbysM51jxmomTsjZwbYDq7bebMDfKQdGXU6Xan_GYmsF53zHI3t6YLfe3YyxVLUxQaO10KMbg-JlydNcZlJEVB7Q2LoQPLZP3pypfZwqxqn-jjPK3j68MNYbbJ5Ej_lFoDwAt84O6MMPO96iVx2CHbr_ect_SPdYkYs4PowXPH6aJex-fn4BlVW9gw</recordid><startdate>20171015</startdate><enddate>20171015</enddate><creator>Guenoun, Daphne</creator><creator>Fouré, Alexandre</creator><creator>Pithioux, Martine</creator><creator>Guis, Sandrine</creator><creator>Le Corroller, Thomas</creator><creator>Mattei, Jean-Pierre</creator><creator>Pauly, Vanessa</creator><creator>Guye, Maxime</creator><creator>Bernard, Monique</creator><creator>Chabrand, Patrick</creator><creator>Champsaur, Pierre</creator><creator>Bendahan, David</creator><general>Wolters Kluwer Health, Inc. All rights reserved</general><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-1023-1526</orcidid><orcidid>https://orcid.org/0000-0002-1502-0958</orcidid><orcidid>https://orcid.org/0000-0002-8180-9973</orcidid><orcidid>https://orcid.org/0000-0001-5283-3504</orcidid></search><sort><creationdate>20171015</creationdate><title>Correlative Analysis of Vertebral Trabecular Bone Microarchitecture and Mechanical Properties: A Combined Ultra-high Field (7 Tesla) MRI and Biomechanical Investigation</title><author>Guenoun, Daphne ; Fouré, Alexandre ; Pithioux, Martine ; Guis, Sandrine ; Le Corroller, Thomas ; Mattei, Jean-Pierre ; Pauly, Vanessa ; Guye, Maxime ; Bernard, Monique ; Chabrand, Patrick ; Champsaur, Pierre ; Bendahan, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3843-a3da4047c909f62bda23fd63f08c1a31a5dcfa4e2bde54ffedce18b5c6e50b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomechanical Phenomena - physiology</topic><topic>Bone Density - physiology</topic><topic>Cadaver</topic><topic>Cancellous Bone - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Lumbar Vertebrae - physiology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Stress, Mechanical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guenoun, Daphne</creatorcontrib><creatorcontrib>Fouré, Alexandre</creatorcontrib><creatorcontrib>Pithioux, Martine</creatorcontrib><creatorcontrib>Guis, Sandrine</creatorcontrib><creatorcontrib>Le Corroller, Thomas</creatorcontrib><creatorcontrib>Mattei, Jean-Pierre</creatorcontrib><creatorcontrib>Pauly, Vanessa</creatorcontrib><creatorcontrib>Guye, Maxime</creatorcontrib><creatorcontrib>Bernard, Monique</creatorcontrib><creatorcontrib>Chabrand, Patrick</creatorcontrib><creatorcontrib>Champsaur, Pierre</creatorcontrib><creatorcontrib>Bendahan, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guenoun, Daphne</au><au>Fouré, Alexandre</au><au>Pithioux, Martine</au><au>Guis, Sandrine</au><au>Le Corroller, Thomas</au><au>Mattei, Jean-Pierre</au><au>Pauly, Vanessa</au><au>Guye, Maxime</au><au>Bernard, Monique</au><au>Chabrand, Patrick</au><au>Champsaur, Pierre</au><au>Bendahan, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlative Analysis of Vertebral Trabecular Bone Microarchitecture and Mechanical Properties: A Combined Ultra-high Field (7 Tesla) MRI and Biomechanical Investigation</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2017-10-15</date><risdate>2017</risdate><volume>42</volume><issue>20</issue><spage>E1165</spage><epage>E1172</epage><pages>E1165-E1172</pages><issn>0362-2436</issn><issn>1529-9430</issn><eissn>1528-1159</eissn><abstract>STUDY DESIGN.High-resolution imaging and biomechanical investigation of ex-vivo vertebrae.
OBJECTIVE.The aim of this study was to assess bone microarchitecture of cadaveric vertebrae using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI) and to determine whether the corresponding microarchitecture parameters were related to bone mineral density (BMD) and bone strength assessed by dual-energy x-ray absorptiometry (DXA) and mechanical compression tests.
SUMMARY OF BACKGROUND DATA.Limitations of DXA for the assessment of bone fragility and osteoporosis have been recognized and criteria of microarchitecture alteration have been included in the definition of osteoporosis. Although vertebral fracture is the most common osteoporotic fracture, no study has assessed directly vertebral trabecular bone microarchitecture.
METHODS.BMD of 24 vertebrae (L2, L3, L4) from eight cadavers was investigated using DXA. The bone volume fraction (BVF), trabecular thickness (Tb.Th), and trabecular spacing (Tb.Sp) of each vertebra were quantified using UHF MRI. Measurements were performed by two operators to characterize the inter-rater reliability. The whole set of specimens underwent mechanical compression tests to failure and the corresponding failure stress was calculated.
RESULTS.The inter-rater reliability for bone microarchitecture parameters was good with intraclass correlation coefficients ranging from 0.82 to 0.94. Failure load and stress were significantly correlated with BVF, Tb.Sp, and BMD (P < 0.05). Tb.Th was only correlated with the failure stress (P < 0.05). Multiple regression analysis demonstrated that the combination of BVF and BMD improved the prediction of the failure stress from an adjusted R = 0.384 for BMD alone to an adjusted R = 0.414.
CONCLUSION.We demonstrated for the first time that the vertebral bone microarchitecture assessed with UHF MRI was significantly correlated with biomechanical parameters. Our data suggest that the multimodal assessment of BMD and trabecular bone microarchitecture with UHF MRI provides additional information on the risk of vertebral bone fracture and might be of interest for the future investigation of selected osteoporotic patients.Level of EvidenceN /A</abstract><cop>United States</cop><pub>Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>28338579</pmid><doi>10.1097/BRS.0000000000002163</doi><orcidid>https://orcid.org/0000-0003-1023-1526</orcidid><orcidid>https://orcid.org/0000-0002-1502-0958</orcidid><orcidid>https://orcid.org/0000-0002-8180-9973</orcidid><orcidid>https://orcid.org/0000-0001-5283-3504</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; ScienceDirect Journals (5 years ago - present) |
| subjects | Absorptiometry, Photon - methods Aged Aged, 80 and over Biomechanical Phenomena - physiology Bone Density - physiology Cadaver Cancellous Bone - diagnostic imaging Female Humans Life Sciences Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Lumbar Vertebrae - physiology Magnetic Resonance Imaging - methods Male Regression Analysis Reproducibility of Results Stress, Mechanical |
| title | Correlative Analysis of Vertebral Trabecular Bone Microarchitecture and Mechanical Properties: A Combined Ultra-high Field (7 Tesla) MRI and Biomechanical Investigation |
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