Comprehensive two dimensional liquid chromatography as analytical strategy for pharmaceutical analysis

•Three RPLCxRPLC systems were defined and successfully used to detect pharmaceutical impurities.•Both degree of orthogonality and practical peak capacity were used to find out suitable 2D-conditions.•About 1000 as effective peak capacity could be achieved in less than 50min in RPLC x RPLC.•The inter...

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Veröffentlicht in:	Journal of Chromatography A 2018-02, Vol.1536, p.195-204
Hauptverfasser:	Iguiniz, Marion, Rouvière, Florent, Corbel, Estelle, Roques, Nicolas, Heinisch, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Chemical Sciences Impurity profiling On-line LCxLC–MS Orthogonality Peak capacity Pharmaceutical analysis
Online-Zugang:	Volltext
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