A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity

Arkadia (Rnf111) is an E3 ubiquitin ligase that plays a central role in the amplification of transforming growth factor beta (TGF-β) signaling responses by targeting for degradation the negative regulators of the pathway, Smad6 and Smad7, and the nuclear co-repressors Ski and Skil (SnoN). Arkadia�...

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Veröffentlicht in:	Journal of molecular biology 2017-07, Vol.429 (15), p.2373-2386
Hauptverfasser:	Birkou, Maria, Chasapis, Christos T., Marousis, Konstantinos D., Loutsidou, Ariadni K., Bentrop, Detlef, Lelli, Moreno, Herrmann, Torsten, Carthy, Jonathon M., Episkopou, Vasso, Spyroulias, Georgios A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - genetics Alanine - metabolism Amino Acid Substitution Analytical chemistry APSY Arginine - genetics Arginine - metabolism Biochemistry, Molecular Biology Chemical Sciences Genes, Reporter Life Sciences Luciferases - analysis Magnetic Resonance Spectroscopy Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism NMR Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Conformation RING domain Rnf111 Signal Transduction TGF-β Transforming Growth Factor beta - metabolism Tryptophan - genetics Tryptophan - metabolism Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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