Characterization of Arsenic Species in Kidney of the Clam Tridacna derasa by Multidimensional Liquid Chromatography-ICPMS and Electrospray Time-of-Flight Tandem Mass Spectrometry
The identification of water-soluble arsenic species in a kidney of the Tridacna clam by electrospray quadrupole/time-of-flight mass spectrometry (ES Q-TOF MS) was investigated. The species were isolated by three-dimensional LC (size exclusion-anion exchange-cation exchange); the elution of arsenic w...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2002-05, Vol.74 (10), p.2370-2378 |
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| creator | MCSHEEHY, Shona SZPUNAR, Joanna LOBINSKI, Ryszard HALDYS, Violette TORTAJADA, Jeanine EDMONDS, John S. |
| description | The identification of water-soluble arsenic species in a kidney of the Tridacna clam by electrospray quadrupole/time-of-flight mass spectrometry (ES Q-TOF MS) was investigated. The species were isolated by three-dimensional LC (size exclusion-anion exchange-cation exchange); the elution of arsenic was monitored by ICPMS. The average accuracy and precision of the molecular mass measurements, studied for a number of organoarsenic standards, were 22 (negative bias) and 15 ppm, respectively. Structural information was obtained in the tandem Q-TOF mode. A total of 15 organoarsenic species were identified, and 13 of these possessed the dimethylarsinoyl group (8 ribofuranosides, 4 acyclic compounds, and 1 dihydroxyfuran). Four of these species were previously unreported. Arsenobetaine and dimethylarsinic acid were also detected. The major species (accounting for up to 50% water-soluble arsenic) was 5-dimethylarsinoyl-2,3,4-trihydroxypentanoic acid. The metabolic interrelationships of these compounds and their significance are briefly discussed. |
| doi_str_mv | 10.1021/ac011136y |
| format | Article |
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The species were isolated by three-dimensional LC (size exclusion-anion exchange-cation exchange); the elution of arsenic was monitored by ICPMS. The average accuracy and precision of the molecular mass measurements, studied for a number of organoarsenic standards, were 22 (negative bias) and 15 ppm, respectively. Structural information was obtained in the tandem Q-TOF mode. A total of 15 organoarsenic species were identified, and 13 of these possessed the dimethylarsinoyl group (8 ribofuranosides, 4 acyclic compounds, and 1 dihydroxyfuran). Four of these species were previously unreported. Arsenobetaine and dimethylarsinic acid were also detected. The major species (accounting for up to 50% water-soluble arsenic) was 5-dimethylarsinoyl-2,3,4-trihydroxypentanoic acid. The metabolic interrelationships of these compounds and their significance are briefly discussed.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac011136y</identifier><identifier>PMID: 12038763</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Analytical chemistry ; Animals ; Applied sciences ; Arsenic ; Arsenicals - analysis ; Arsenicals - pharmacokinetics ; Biotransformation ; Bivalvia - chemistry ; Bivalvia - metabolism ; Chemical Sciences ; Chemistry ; Chromatography, High Pressure Liquid - methods ; Exact sciences and technology ; Global environmental pollution ; Kidney - chemistry ; Mollusks ; Pollution ; Spectrometric and optical methods ; Spectrometry, Mass, Electrospray Ionization - methods ; Spectrum analysis ; Tridacna derasa</subject><ispartof>Analytical chemistry (Washington), 2002-05, Vol.74 (10), p.2370-2378</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Chemical Society May 15, 2002</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-5644-4933</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13665908$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12038763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01560739$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>MCSHEEHY, Shona</creatorcontrib><creatorcontrib>SZPUNAR, Joanna</creatorcontrib><creatorcontrib>LOBINSKI, Ryszard</creatorcontrib><creatorcontrib>HALDYS, Violette</creatorcontrib><creatorcontrib>TORTAJADA, Jeanine</creatorcontrib><creatorcontrib>EDMONDS, John S.</creatorcontrib><title>Characterization of Arsenic Species in Kidney of the Clam Tridacna derasa by Multidimensional Liquid Chromatography-ICPMS and Electrospray Time-of-Flight Tandem Mass Spectrometry</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>The identification of water-soluble arsenic species in a kidney of the Tridacna clam by electrospray quadrupole/time-of-flight mass spectrometry (ES Q-TOF MS) was investigated. The species were isolated by three-dimensional LC (size exclusion-anion exchange-cation exchange); the elution of arsenic was monitored by ICPMS. The average accuracy and precision of the molecular mass measurements, studied for a number of organoarsenic standards, were 22 (negative bias) and 15 ppm, respectively. Structural information was obtained in the tandem Q-TOF mode. A total of 15 organoarsenic species were identified, and 13 of these possessed the dimethylarsinoyl group (8 ribofuranosides, 4 acyclic compounds, and 1 dihydroxyfuran). Four of these species were previously unreported. Arsenobetaine and dimethylarsinic acid were also detected. The major species (accounting for up to 50% water-soluble arsenic) was 5-dimethylarsinoyl-2,3,4-trihydroxypentanoic acid. The metabolic interrelationships of these compounds and their significance are briefly discussed.</description><subject>Analytical chemistry</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Arsenic</subject><subject>Arsenicals - analysis</subject><subject>Arsenicals - pharmacokinetics</subject><subject>Biotransformation</subject><subject>Bivalvia - chemistry</subject><subject>Bivalvia - metabolism</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Exact sciences and technology</subject><subject>Global environmental pollution</subject><subject>Kidney - chemistry</subject><subject>Mollusks</subject><subject>Pollution</subject><subject>Spectrometric and optical methods</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Spectrum analysis</subject><subject>Tridacna derasa</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1u1DAQAOAIgehSOPACyEIqEoeAfxLbOa6itlvYFVV3Ecdo4jiNS_5qO4jwWDwhXnYpEhdOlma-Gc_YUfSS4HcEU_IeFCaEMD4_ihYkpTjmUtLH0QJjzGIqMD6Jnjl3h4PChD-NTgjFTArOFtHPvAELymtrfoA3Q4-GGi2t071RaDtqZbRDpkcfTdXreZ_0jUZ5Cx3aWVOB6gFV2oIDVM5oM7XeVKbTvQutoEVrcz-ZCuWNHTrww62FsZnjq_x6s0XQV-i81crbwY0WZrQLhfFQxxetuW082gWgO7QB535PElynvZ2fR09qaJ1-cTxPo88X57t8Fa8_XV7ly3XcJIz5mFHOVQKyTCRwqFValUAJZbQSdVlBmiVMEC1KJRQTtCozAozjJNGJpDLNJDuN3h76NtAWozUd2LkYwBSr5brYxzBJORYs-0aCfXOwox3uJ-180RmndNtCr4fJFYIIKmSW_RcSmZEsI0mAr_-Bd8Nkw5u6ghIhOcZcBPTqiKay09XDlH_-N4CzIwCnoK0t9Mq4v45xnmZ4v2t8cMZ5_f0hD_ZrEa4RabG73haXN6v8wzq7Kb6wXwL2w1o</recordid><startdate>20020515</startdate><enddate>20020515</enddate><creator>MCSHEEHY, Shona</creator><creator>SZPUNAR, Joanna</creator><creator>LOBINSKI, Ryszard</creator><creator>HALDYS, Violette</creator><creator>TORTAJADA, Jeanine</creator><creator>EDMONDS, John S.</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7QH</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5644-4933</orcidid></search><sort><creationdate>20020515</creationdate><title>Characterization of Arsenic Species in Kidney of the Clam Tridacna derasa by Multidimensional Liquid Chromatography-ICPMS and Electrospray Time-of-Flight Tandem Mass Spectrometry</title><author>MCSHEEHY, Shona ; SZPUNAR, Joanna ; LOBINSKI, Ryszard ; HALDYS, Violette ; TORTAJADA, Jeanine ; EDMONDS, John S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h433t-3266c4a8b48a6afc5dba21232d7fbda594371e7bc7c372db91a36044e48285983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analytical chemistry</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Arsenic</topic><topic>Arsenicals - analysis</topic><topic>Arsenicals - pharmacokinetics</topic><topic>Biotransformation</topic><topic>Bivalvia - chemistry</topic><topic>Bivalvia - metabolism</topic><topic>Chemical Sciences</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Exact sciences and technology</topic><topic>Global environmental pollution</topic><topic>Kidney - chemistry</topic><topic>Mollusks</topic><topic>Pollution</topic><topic>Spectrometric and optical methods</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Spectrum analysis</topic><topic>Tridacna derasa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCSHEEHY, Shona</creatorcontrib><creatorcontrib>SZPUNAR, Joanna</creatorcontrib><creatorcontrib>LOBINSKI, Ryszard</creatorcontrib><creatorcontrib>HALDYS, Violette</creatorcontrib><creatorcontrib>TORTAJADA, Jeanine</creatorcontrib><creatorcontrib>EDMONDS, John S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Aqualine</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MCSHEEHY, Shona</au><au>SZPUNAR, Joanna</au><au>LOBINSKI, Ryszard</au><au>HALDYS, Violette</au><au>TORTAJADA, Jeanine</au><au>EDMONDS, John S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Arsenic Species in Kidney of the Clam Tridacna derasa by Multidimensional Liquid Chromatography-ICPMS and Electrospray Time-of-Flight Tandem Mass Spectrometry</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2002-05-15</date><risdate>2002</risdate><volume>74</volume><issue>10</issue><spage>2370</spage><epage>2378</epage><pages>2370-2378</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>The identification of water-soluble arsenic species in a kidney of the Tridacna clam by electrospray quadrupole/time-of-flight mass spectrometry (ES Q-TOF MS) was investigated. The species were isolated by three-dimensional LC (size exclusion-anion exchange-cation exchange); the elution of arsenic was monitored by ICPMS. The average accuracy and precision of the molecular mass measurements, studied for a number of organoarsenic standards, were 22 (negative bias) and 15 ppm, respectively. Structural information was obtained in the tandem Q-TOF mode. A total of 15 organoarsenic species were identified, and 13 of these possessed the dimethylarsinoyl group (8 ribofuranosides, 4 acyclic compounds, and 1 dihydroxyfuran). Four of these species were previously unreported. Arsenobetaine and dimethylarsinic acid were also detected. The major species (accounting for up to 50% water-soluble arsenic) was 5-dimethylarsinoyl-2,3,4-trihydroxypentanoic acid. The metabolic interrelationships of these compounds and their significance are briefly discussed.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>12038763</pmid><doi>10.1021/ac011136y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5644-4933</orcidid></addata></record> |
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| subjects | Analytical chemistry Animals Applied sciences Arsenic Arsenicals - analysis Arsenicals - pharmacokinetics Biotransformation Bivalvia - chemistry Bivalvia - metabolism Chemical Sciences Chemistry Chromatography, High Pressure Liquid - methods Exact sciences and technology Global environmental pollution Kidney - chemistry Mollusks Pollution Spectrometric and optical methods Spectrometry, Mass, Electrospray Ionization - methods Spectrum analysis Tridacna derasa |
| title | Characterization of Arsenic Species in Kidney of the Clam Tridacna derasa by Multidimensional Liquid Chromatography-ICPMS and Electrospray Time-of-Flight Tandem Mass Spectrometry |
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