Effect of the Interaction of the Amyloid β (1–42) Peptide with Short Single-Stranded Synthetic Nucleotide Sequences: Morphological Characterization of the Inhibition of Fibrils Formation and Fibrils Disassembly

The formation of extracellular neuritic plaques in the brain of individuals who suffered from Alzheimer’s disease (AD) is a major pathological hallmark. These plaques consist of filamentous aggregates of the amyloid beta (1–42) (Aβ42) proteins. Prevention or reduction of the formation of these fibri...

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Veröffentlicht in:	Biomacromolecules 2014-09, Vol.15 (9), p.3253-3258
Hauptverfasser:	Abraham, Jancy Nixon, Kedracki, Dawid, Prado, Enora, Gourmel, Charlotte, Maroni, Plinio, Nardin, Corinne
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Chemical Sciences Humans Oligonucleotides - chemistry Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Aggregation, Pathological Spectroscopy, Fourier Transform Infrared
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