Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons

Dopaminergic neurons in the ventral tegmental area (VTA) contribute to mediating stress susceptibility and resilience. The authors demonstrate that noradrenergic neurons in the locus coeruleus can drive the activity of these dopaminergic VTA neurons to generate a resilient response to chronic stress...

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Veröffentlicht in:	Nature neuroscience 2016-04, Vol.19 (4), p.560-563
Hauptverfasser:	Isingrini, Elsa, Perret, Léa, Rainer, Quentin, Amilhon, Bénédicte, Guma, Elisa, Tanti, Arnaud, Martin, Garance, Robinson, Jennifer, Moquin, Luc, Marti, Fabio, Mechawar, Naguib, Williams, Sylvain, Gratton, Alain, Giros, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/19 14/32 14/35 631/378/1689/1414 631/378/1689/1831 631/378/3920 64/60 692/699/476/1414 9/74 Adrenergic mechanisms Adrenergic Neurons - physiology Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedicine brief-communication Chronic Disease Dopamine Dopaminergic Neurons - metabolism Health aspects Life Sciences Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neural Inhibition - physiology Neurobiology Neurons and Cognition Neurosciences Norepinephrine - physiology Observations Resilience, Psychological Social interaction Stress Stress (Physiology) Stress, Psychological - genetics Stress, Psychological - metabolism Stress, Psychological - psychology Ventral Tegmental Area - metabolism Vesicular Monoamine Transport Proteins - deficiency Vesicular Monoamine Transport Proteins - genetics
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