Extracellular Signal-Regulated Protein Kinases 1 and 2 Activation by Addictive Drugs: A Signal Toward Pathological Adaptation

Addiction is a chronic and relapsing psychiatric disorder that is thought to occur in vulnerable individuals. Synaptic plasticity evoked by drugs of abuse in the so-called neuronal circuits of reward has been proposed to underlie behavioral adaptations that characterize addiction. By increasing dopa...

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Veröffentlicht in:	Biological psychiatry (1969) 2014-12, Vol.76 (12), p.917-926
Hauptverfasser:	Pascoli, Vincent, Cahill, Emma, Bellivier, Frank, Caboche, Jocelyne, Vanhoutte, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Animals Biological and medical sciences cocaine Cocaine - pharmacology Corpus Striatum - cytology Corpus Striatum - drug effects dopamine Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Enzyme Activation - drug effects extracellular signal-regulated kinases 1 and 2 (ERK1/2) glutamate Glutamic Acid - metabolism Humans Life Sciences Medical sciences Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 - metabolism Neurons and Cognition Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Signal Transduction - drug effects synaptic plasticity
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