Heterozygote advantage at MHC DRB may influence response to infectious disease epizootics

The effect of MHC polymorphism on individual fitness variation in the wild remains equivocal; however, much evidence suggests that heterozygote advantage is a major determinant. To understand the contribution of MHC polymorphism to individual disease resistance or susceptibility in natural populatio...

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Veröffentlicht in:	Molecular ecology 2015-04, Vol.24 (7), p.1419-1432
Hauptverfasser:	Osborne, Amy J., Pearson, John, Negro, Sandra S., Chilvers, B. Louise, Kennedy, Martin A., Gemmell, Neil J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Infections - genetics Bacterial Infections - veterinary conservation genetics disease biology ecological genetics Epidemics Gene Frequency Genes, MHC Class II Genetic Predisposition to Disease Genotype Haplotypes Heterozygote Life Sciences mammals Microsatellite Repeats Molecular Sequence Data natural selection and contemporary evolution New Zealand Phocarctos hookeri population genetics-empirical Sea Lions - genetics Sea Lions - microbiology Sequence Analysis, DNA
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