Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca‐1 and Pw1 promoters

Understanding the regulation of the stem cell fate is fundamental for designing novel regenerative medicine strategies. Previous studies have suggested that pharmacological treatments with small molecules provide a robust and reversible regulation of the stem cell program. Previously, we showed that...

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Veröffentlicht in:	The FASEB journal 2016-04, Vol.30 (4), p.1404-1415
Hauptverfasser:	Smeriglio, Piera, Alonso‐Martin, Sonia, Masciarelli, Silvia, Madaro, Luca, Iosue, Ilaria, Marrocco, Valeria, Relaix, Frédéric, Fazi, Francesco, Marazzi, Giovanna, Sassoon, David A., Bouché, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - genetics Biochemistry, Molecular Biology Blotting, Western Cell Line cell reprogramming cell stemness Cells, Cultured Epigenesis, Genetic Gene Expression - drug effects Genomics Kruppel-Like Transcription Factors - genetics Life Sciences Membrane Proteins - genetics Mice, Nude Mice, Transgenic Microscopy, Fluorescence muscle cell fate Muscle Cells - cytology Muscle Cells - drug effects Muscle Cells - metabolism muscle regeneration Muscle, Skeletal - drug effects Muscle, Skeletal - injuries Muscle, Skeletal - physiopathology Myoblasts, Skeletal - cytology Myoblasts, Skeletal - drug effects Myoblasts, Skeletal - metabolism Promoter Regions, Genetic - genetics Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - metabolism PW1 interstitial cells Regeneration - drug effects Reverse Transcriptase Polymerase Chain Reaction Vanadium Compounds - pharmacology
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