Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection
•Micro-interface embedded in silicon microneedle array for liquid–liquid electrochemistry.•Detection of sub-micromolar concentrations of propranolol in physiological solutions.•No need of extraction of physiological fluid for analysis. This report describes a method for integration of a gel–liquid i...
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| Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2014-10, Vol.201, p.572-578 |
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| container_title | Sensors and actuators. B, Chemical |
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| creator | Vazquez, Patricia Herzog, Grégoire O’Mahony, Conor O’Brien, Joseph Scully, James Blake, Alan O’Mathuna, Cian Galvin, Paul |
| description | •Micro-interface embedded in silicon microneedle array for liquid–liquid electrochemistry.•Detection of sub-micromolar concentrations of propranolol in physiological solutions.•No need of extraction of physiological fluid for analysis.
This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM. |
| doi_str_mv | 10.1016/j.snb.2014.04.080 |
| format | Article |
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This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM.</description><subject>Chemical Sciences</subject><subject>ITIES</subject><subject>Micro-interfaces</subject><subject>Microneedles</subject><subject>Minimally invasive</subject><subject>Stripping voltammetry</subject><subject>β-Blocker drug</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kMFKw0AURQdRsFY_wN1sXSS-mWQyCa5KUStU3Oh6mE5e2ilJJs6kle78B__QLzGh4lK48OBxz4V7CblmEDNg2e02Du0q5sDSGAblcEImLJdJlICUp2QCBRdRCiDOyUUIWwBIkwwmxD5b410wrrOGrrH-_vyq7fvOltS2PfpKGww07LrO-R5LujrQjatr90GbkWsRyxqp9l4faOU83bu6102DvR_iSr9b0xJ7NL117SU5q3Qd8Or3Tsnbw_3rfBEtXx6f5rNlZBKZ9pEUIkMUhvNcalblIE3KkzLTichMnklpKp4wnVcpFmxlCiyQCw6aS6lBpiaZkptj7kbXqvO20f6gnLZqMVuq8QdMgOBM7tngZUfvuEHwWP0BDNS4q9qqYVc17qpgUA4Dc3dkcCixt-hVMBZbg6X1Q1NVOvsP_QOrgYLZ</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Vazquez, Patricia</creator><creator>Herzog, Grégoire</creator><creator>O’Mahony, Conor</creator><creator>O’Brien, Joseph</creator><creator>Scully, James</creator><creator>Blake, Alan</creator><creator>O’Mathuna, Cian</creator><creator>Galvin, Paul</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-5392-6451</orcidid><orcidid>https://orcid.org/0000-0003-1932-9300</orcidid></search><sort><creationdate>20141001</creationdate><title>Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection</title><author>Vazquez, Patricia ; Herzog, Grégoire ; O’Mahony, Conor ; O’Brien, Joseph ; Scully, James ; Blake, Alan ; O’Mathuna, Cian ; Galvin, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-7556ee5c2287a1f807c423d6a356c8677cf231a8f4e91bc9e9e2520a277a074c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Chemical Sciences</topic><topic>ITIES</topic><topic>Micro-interfaces</topic><topic>Microneedles</topic><topic>Minimally invasive</topic><topic>Stripping voltammetry</topic><topic>β-Blocker drug</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vazquez, Patricia</creatorcontrib><creatorcontrib>Herzog, Grégoire</creatorcontrib><creatorcontrib>O’Mahony, Conor</creatorcontrib><creatorcontrib>O’Brien, Joseph</creatorcontrib><creatorcontrib>Scully, James</creatorcontrib><creatorcontrib>Blake, Alan</creatorcontrib><creatorcontrib>O’Mathuna, Cian</creatorcontrib><creatorcontrib>Galvin, Paul</creatorcontrib><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Sensors and actuators. B, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vazquez, Patricia</au><au>Herzog, Grégoire</au><au>O’Mahony, Conor</au><au>O’Brien, Joseph</au><au>Scully, James</au><au>Blake, Alan</au><au>O’Mathuna, Cian</au><au>Galvin, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection</atitle><jtitle>Sensors and actuators. B, Chemical</jtitle><date>2014-10-01</date><risdate>2014</risdate><volume>201</volume><spage>572</spage><epage>578</epage><pages>572-578</pages><issn>0925-4005</issn><eissn>1873-3077</eissn><abstract>•Micro-interface embedded in silicon microneedle array for liquid–liquid electrochemistry.•Detection of sub-micromolar concentrations of propranolol in physiological solutions.•No need of extraction of physiological fluid for analysis.
This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2014.04.080</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5392-6451</orcidid><orcidid>https://orcid.org/0000-0003-1932-9300</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Sensors and actuators. B, Chemical, 2014-10, Vol.201, p.572-578 |
| issn | 0925-4005 1873-3077 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Chemical Sciences ITIES Micro-interfaces Microneedles Minimally invasive Stripping voltammetry β-Blocker drug |
| title | Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection |
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