Conditions to minimize soft single biomolecule deformation when imaging with atomic force microscopy

A recurrent interrogation when imaging soft biomolecules using atomic force microscopy (AFM) is the putative deformation of molecules leading to a bias in recording true topographical surfaces. Deformation of biomolecules comes from three sources: sample instability, adsorption to the imaging substr...

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Veröffentlicht in:	Journal of structural biology 2017-03, Vol.197 (3), p.322-329
Hauptverfasser:	Godon, Christian, Teulon, Jean-Marie, Odorico, Michael, Basset, Christian, Meillan, Matthieu, Vellutini, Luc, Chen, Shu-wen W., Pellequer, Jean-Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	AFM topography Biochemistry, Molecular Biology Life Sciences Mica Microscopy, Atomic Force - methods Peakforce tapping Self-assembled monolayers Single molecule deformation Structural Biology Tobacco mosaic virus Tobacco Mosaic Virus - ultrastructure
Online-Zugang:	Volltext
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