The onset of left ventricular diastolic dysfunction in SHR rats is not related to hypertrophy or hypertension

Left ventricular (LV) diastolic dysfunction, particularly relaxation abnormalities, are known to be associated with the development of LV hypertrophy (LVH). Preliminary human and animal studies suggested that early LV diastolic dysfunction may be revealed independently of LVH. However, whether LV di...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2012-04, Vol.302 (7), p.H1524-H1532
Hauptverfasser:	Dupont, S, Maizel, J, Mentaverri, R, Chillon, J-M, Six, I, Giummelly, P, Brazier, M, Choukroun, G, Tribouilloy, C, Massy, Z A, Slama, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Blood Pressure - physiology Blotting, Western Calcium Channels - genetics Calcium Channels - physiology Cardiomegaly - complications Cardiomegaly - physiopathology Cardiovascular disease Collagen - metabolism Coronary Circulation - physiology Echocardiography Echocardiography, Doppler Fluorescent Dyes Fura-2 Gene expression Homeostasis Hypertension Hypertension - complications Hypertension - genetics Hypertension - physiopathology In Vitro Techniques Life Sciences Microsomes - drug effects Myocytes, Cardiac - drug effects Proteins Rats Rats, Inbred SHR Rats, Inbred WKY Real-Time Polymerase Chain Reaction RNA - biosynthesis RNA - genetics Rodents Sarcoplasmic Reticulum Calcium-Transporting ATPases - biosynthesis Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology
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