Different outcome of T cell acute lymphoblastic leukemia with translocation t(11;14) treated in two consecutive children leukemia group EORTC trials
Acute lymphoblastic leukemia of T cell lineage (T-ALL) is an aggressive malignant disease which accounts for 15 % of childhood ALL. T(11;14) is the more frequent chromosomal abnormality in childhood T-ALL, but its prognostic value remained controversial. Our aim was to analyze the outcome of childho...
Gespeichert in:
| Veröffentlicht in: | Annals of hematology 2016-01, Vol.95 (1), p.93-103 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103 |
|---|---|
| container_issue | 1 |
| container_start_page | 93 |
| container_title | Annals of hematology |
| container_volume | 95 |
| creator | Simon, Pauline Suciu, Stefan Clappier, Emmanuelle Cave, Hélène Sirvent, Nicolas Plat, Geneviève Thyss, Antoine Mechinaud, Françoise Costa, Vitor M. Ferster, Alina Lutz, Patrick Mazingue, Françoise Plantaz, Dominique Plouvier, Emmanuel Bertrand, Yves Benoit, Yves Dastugue, Nicole Rohrlich, Pierre S. |
| description | Acute lymphoblastic leukemia of T cell lineage (T-ALL) is an aggressive malignant disease which accounts for 15 % of childhood ALL. T(11;14) is the more frequent chromosomal abnormality in childhood T-ALL, but its prognostic value remained controversial. Our aim was to analyze the outcome of childhood T-ALL with t(11;14) to know if the presence of this translocation is associated with a poor prognosis. We conducted a retrospective study from a series of 20 patients with t(11;14), treated in two consecutive trials from the European Organization for Research and Treatment of Cancer Children Leukemia Group over a 19-year period from 1989 to 2008. There were no significant differences between the 2 consecutive groups of patients with t(11;14) regarding the clinical and biological features at diagnosis. Among 19 patients who reached complete remission, 9 patients relapsed. We noticed 7 deaths all relapse- or failure-related. In the 58881 study, a presence of t(11;14) was associated with a poor outcome with an event-free survival at 5 years at 22.2 % versus 65.1 % for the non-t(11;14) T-ALL (
p
= 0.0004). In the more recent protocol, the outcome of T-ALL with t(11;14) reached that of non-t(11;14) T-ALL with an event-free survival at 5 years at 65.5 versus 74.9 % (
p
= 0.93). The presence of t(11;14) appeared as a poor prognostic feature in the 58881 trial whereas this abnormality no longer affected the outcome in the 58951 study. This difference is probably explained by the more intensive chemotherapy in the latest trial. |
| doi_str_mv | 10.1007/s00277-015-2515-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01482631v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3911267701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-defec1b479ede065919998072f4d6df0131b3b3a580cb0da408131b3fc3233373</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EokPLA7BBlti0i8D1T_7EqpoWijRSpWpYW45z03FJ4sF2WvU9-sB1SCkICS9s6fi75177EPKOwUcGUH4KALwsM2B5xvO0VS_IiknBM8gr-ZKsoBZ1lqd1QN6EcAPAeCX5a3LAC5nUsl6RhzPbdehxjNRN0bgBqevolhrse6rNFJH298N-55peh2gN7XH6gYPV9M7GHY1ej6F3RkfrRhqPGfvM5EmSUUdsqU3anaPGjQGTl71Fana2b1O_P0bX3k17en55tV2nQqv7cERedenAt0_nIfn-5Xy7vsg2l1-_rU83mZFlEbMWOzSskWWNLUKR16yu6wpK3sm2aDtggjWiETqvwDTQagnVL6kzggshSnFIThbfne7V3ttB-3vltFUXpxs1a8BkxQvBbllijxd2793PCUNUgw3zL-kR3RQUK3MJNecwox_-QW_c5Mf0kpkSrJKQi0SxhTLeheCxe56AgZrjVUu8aYhczfGqKtW8f3KemgHb54rfeSaAL0BIV-M1-r9a_9f1EYiIr2U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1753184053</pqid></control><display><type>article</type><title>Different outcome of T cell acute lymphoblastic leukemia with translocation t(11;14) treated in two consecutive children leukemia group EORTC trials</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Simon, Pauline ; Suciu, Stefan ; Clappier, Emmanuelle ; Cave, Hélène ; Sirvent, Nicolas ; Plat, Geneviève ; Thyss, Antoine ; Mechinaud, Françoise ; Costa, Vitor M. ; Ferster, Alina ; Lutz, Patrick ; Mazingue, Françoise ; Plantaz, Dominique ; Plouvier, Emmanuel ; Bertrand, Yves ; Benoit, Yves ; Dastugue, Nicole ; Rohrlich, Pierre S.</creator><creatorcontrib>Simon, Pauline ; Suciu, Stefan ; Clappier, Emmanuelle ; Cave, Hélène ; Sirvent, Nicolas ; Plat, Geneviève ; Thyss, Antoine ; Mechinaud, Françoise ; Costa, Vitor M. ; Ferster, Alina ; Lutz, Patrick ; Mazingue, Françoise ; Plantaz, Dominique ; Plouvier, Emmanuel ; Bertrand, Yves ; Benoit, Yves ; Dastugue, Nicole ; Rohrlich, Pierre S. ; Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC) ; on behalf of the Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)</creatorcontrib><description>Acute lymphoblastic leukemia of T cell lineage (T-ALL) is an aggressive malignant disease which accounts for 15 % of childhood ALL. T(11;14) is the more frequent chromosomal abnormality in childhood T-ALL, but its prognostic value remained controversial. Our aim was to analyze the outcome of childhood T-ALL with t(11;14) to know if the presence of this translocation is associated with a poor prognosis. We conducted a retrospective study from a series of 20 patients with t(11;14), treated in two consecutive trials from the European Organization for Research and Treatment of Cancer Children Leukemia Group over a 19-year period from 1989 to 2008. There were no significant differences between the 2 consecutive groups of patients with t(11;14) regarding the clinical and biological features at diagnosis. Among 19 patients who reached complete remission, 9 patients relapsed. We noticed 7 deaths all relapse- or failure-related. In the 58881 study, a presence of t(11;14) was associated with a poor outcome with an event-free survival at 5 years at 22.2 % versus 65.1 % for the non-t(11;14) T-ALL (
p
= 0.0004). In the more recent protocol, the outcome of T-ALL with t(11;14) reached that of non-t(11;14) T-ALL with an event-free survival at 5 years at 65.5 versus 74.9 % (
p
= 0.93). The presence of t(11;14) appeared as a poor prognostic feature in the 58881 trial whereas this abnormality no longer affected the outcome in the 58951 study. This difference is probably explained by the more intensive chemotherapy in the latest trial.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-015-2515-8</identifier><identifier>PMID: 26455579</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Child ; Child, Preschool ; Chromosomes, Human, Pair 11 - genetics ; Chromosomes, Human, Pair 14 - genetics ; Cohort Studies ; Economics and Finance ; Female ; Hematology ; Human health and pathology ; Humanities and Social Sciences ; Humans ; Life Sciences ; Male ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Prospective Studies ; Psychiatrics and mental health ; Psychology ; Retrospective Studies ; Santé publique et épidémiologie ; Survival Rate - trends ; Translocation, Genetic - genetics ; Treatment Outcome</subject><ispartof>Annals of hematology, 2016-01, Vol.95 (1), p.93-103</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-defec1b479ede065919998072f4d6df0131b3b3a580cb0da408131b3fc3233373</citedby><cites>FETCH-LOGICAL-c476t-defec1b479ede065919998072f4d6df0131b3b3a580cb0da408131b3fc3233373</cites><orcidid>0000-0003-4693-1671 ; 0000-0002-3257-0302 ; 0000-0002-9920-8359</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-015-2515-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-015-2515-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26455579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01482631$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Simon, Pauline</creatorcontrib><creatorcontrib>Suciu, Stefan</creatorcontrib><creatorcontrib>Clappier, Emmanuelle</creatorcontrib><creatorcontrib>Cave, Hélène</creatorcontrib><creatorcontrib>Sirvent, Nicolas</creatorcontrib><creatorcontrib>Plat, Geneviève</creatorcontrib><creatorcontrib>Thyss, Antoine</creatorcontrib><creatorcontrib>Mechinaud, Françoise</creatorcontrib><creatorcontrib>Costa, Vitor M.</creatorcontrib><creatorcontrib>Ferster, Alina</creatorcontrib><creatorcontrib>Lutz, Patrick</creatorcontrib><creatorcontrib>Mazingue, Françoise</creatorcontrib><creatorcontrib>Plantaz, Dominique</creatorcontrib><creatorcontrib>Plouvier, Emmanuel</creatorcontrib><creatorcontrib>Bertrand, Yves</creatorcontrib><creatorcontrib>Benoit, Yves</creatorcontrib><creatorcontrib>Dastugue, Nicole</creatorcontrib><creatorcontrib>Rohrlich, Pierre S.</creatorcontrib><creatorcontrib>Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)</creatorcontrib><creatorcontrib>on behalf of the Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)</creatorcontrib><title>Different outcome of T cell acute lymphoblastic leukemia with translocation t(11;14) treated in two consecutive children leukemia group EORTC trials</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>Acute lymphoblastic leukemia of T cell lineage (T-ALL) is an aggressive malignant disease which accounts for 15 % of childhood ALL. T(11;14) is the more frequent chromosomal abnormality in childhood T-ALL, but its prognostic value remained controversial. Our aim was to analyze the outcome of childhood T-ALL with t(11;14) to know if the presence of this translocation is associated with a poor prognosis. We conducted a retrospective study from a series of 20 patients with t(11;14), treated in two consecutive trials from the European Organization for Research and Treatment of Cancer Children Leukemia Group over a 19-year period from 1989 to 2008. There were no significant differences between the 2 consecutive groups of patients with t(11;14) regarding the clinical and biological features at diagnosis. Among 19 patients who reached complete remission, 9 patients relapsed. We noticed 7 deaths all relapse- or failure-related. In the 58881 study, a presence of t(11;14) was associated with a poor outcome with an event-free survival at 5 years at 22.2 % versus 65.1 % for the non-t(11;14) T-ALL (
p
= 0.0004). In the more recent protocol, the outcome of T-ALL with t(11;14) reached that of non-t(11;14) T-ALL with an event-free survival at 5 years at 65.5 versus 74.9 % (
p
= 0.93). The presence of t(11;14) appeared as a poor prognostic feature in the 58881 trial whereas this abnormality no longer affected the outcome in the 58951 study. This difference is probably explained by the more intensive chemotherapy in the latest trial.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>Cohort Studies</subject><subject>Economics and Finance</subject><subject>Female</subject><subject>Hematology</subject><subject>Human health and pathology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Prospective Studies</subject><subject>Psychiatrics and mental health</subject><subject>Psychology</subject><subject>Retrospective Studies</subject><subject>Santé publique et épidémiologie</subject><subject>Survival Rate - trends</subject><subject>Translocation, Genetic - genetics</subject><subject>Treatment Outcome</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1u1DAUhS0EokPLA7BBlti0i8D1T_7EqpoWijRSpWpYW45z03FJ4sF2WvU9-sB1SCkICS9s6fi75177EPKOwUcGUH4KALwsM2B5xvO0VS_IiknBM8gr-ZKsoBZ1lqd1QN6EcAPAeCX5a3LAC5nUsl6RhzPbdehxjNRN0bgBqevolhrse6rNFJH298N-55peh2gN7XH6gYPV9M7GHY1ej6F3RkfrRhqPGfvM5EmSUUdsqU3anaPGjQGTl71Fana2b1O_P0bX3k17en55tV2nQqv7cERedenAt0_nIfn-5Xy7vsg2l1-_rU83mZFlEbMWOzSskWWNLUKR16yu6wpK3sm2aDtggjWiETqvwDTQagnVL6kzggshSnFIThbfne7V3ttB-3vltFUXpxs1a8BkxQvBbllijxd2793PCUNUgw3zL-kR3RQUK3MJNecwox_-QW_c5Mf0kpkSrJKQi0SxhTLeheCxe56AgZrjVUu8aYhczfGqKtW8f3KemgHb54rfeSaAL0BIV-M1-r9a_9f1EYiIr2U</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Simon, Pauline</creator><creator>Suciu, Stefan</creator><creator>Clappier, Emmanuelle</creator><creator>Cave, Hélène</creator><creator>Sirvent, Nicolas</creator><creator>Plat, Geneviève</creator><creator>Thyss, Antoine</creator><creator>Mechinaud, Françoise</creator><creator>Costa, Vitor M.</creator><creator>Ferster, Alina</creator><creator>Lutz, Patrick</creator><creator>Mazingue, Françoise</creator><creator>Plantaz, Dominique</creator><creator>Plouvier, Emmanuel</creator><creator>Bertrand, Yves</creator><creator>Benoit, Yves</creator><creator>Dastugue, Nicole</creator><creator>Rohrlich, Pierre S.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>BXJBU</scope><orcidid>https://orcid.org/0000-0003-4693-1671</orcidid><orcidid>https://orcid.org/0000-0002-3257-0302</orcidid><orcidid>https://orcid.org/0000-0002-9920-8359</orcidid></search><sort><creationdate>20160101</creationdate><title>Different outcome of T cell acute lymphoblastic leukemia with translocation t(11;14) treated in two consecutive children leukemia group EORTC trials</title><author>Simon, Pauline ; Suciu, Stefan ; Clappier, Emmanuelle ; Cave, Hélène ; Sirvent, Nicolas ; Plat, Geneviève ; Thyss, Antoine ; Mechinaud, Françoise ; Costa, Vitor M. ; Ferster, Alina ; Lutz, Patrick ; Mazingue, Françoise ; Plantaz, Dominique ; Plouvier, Emmanuel ; Bertrand, Yves ; Benoit, Yves ; Dastugue, Nicole ; Rohrlich, Pierre S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-defec1b479ede065919998072f4d6df0131b3b3a580cb0da408131b3fc3233373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>Cohort Studies</topic><topic>Economics and Finance</topic><topic>Female</topic><topic>Hematology</topic><topic>Human health and pathology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality</topic><topic>Prospective Studies</topic><topic>Psychiatrics and mental health</topic><topic>Psychology</topic><topic>Retrospective Studies</topic><topic>Santé publique et épidémiologie</topic><topic>Survival Rate - trends</topic><topic>Translocation, Genetic - genetics</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simon, Pauline</creatorcontrib><creatorcontrib>Suciu, Stefan</creatorcontrib><creatorcontrib>Clappier, Emmanuelle</creatorcontrib><creatorcontrib>Cave, Hélène</creatorcontrib><creatorcontrib>Sirvent, Nicolas</creatorcontrib><creatorcontrib>Plat, Geneviève</creatorcontrib><creatorcontrib>Thyss, Antoine</creatorcontrib><creatorcontrib>Mechinaud, Françoise</creatorcontrib><creatorcontrib>Costa, Vitor M.</creatorcontrib><creatorcontrib>Ferster, Alina</creatorcontrib><creatorcontrib>Lutz, Patrick</creatorcontrib><creatorcontrib>Mazingue, Françoise</creatorcontrib><creatorcontrib>Plantaz, Dominique</creatorcontrib><creatorcontrib>Plouvier, Emmanuel</creatorcontrib><creatorcontrib>Bertrand, Yves</creatorcontrib><creatorcontrib>Benoit, Yves</creatorcontrib><creatorcontrib>Dastugue, Nicole</creatorcontrib><creatorcontrib>Rohrlich, Pierre S.</creatorcontrib><creatorcontrib>Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)</creatorcontrib><creatorcontrib>on behalf of the Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>HAL-SHS: Archive ouverte en Sciences de l'Homme et de la Société</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simon, Pauline</au><au>Suciu, Stefan</au><au>Clappier, Emmanuelle</au><au>Cave, Hélène</au><au>Sirvent, Nicolas</au><au>Plat, Geneviève</au><au>Thyss, Antoine</au><au>Mechinaud, Françoise</au><au>Costa, Vitor M.</au><au>Ferster, Alina</au><au>Lutz, Patrick</au><au>Mazingue, Françoise</au><au>Plantaz, Dominique</au><au>Plouvier, Emmanuel</au><au>Bertrand, Yves</au><au>Benoit, Yves</au><au>Dastugue, Nicole</au><au>Rohrlich, Pierre S.</au><aucorp>Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)</aucorp><aucorp>on behalf of the Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different outcome of T cell acute lymphoblastic leukemia with translocation t(11;14) treated in two consecutive children leukemia group EORTC trials</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>95</volume><issue>1</issue><spage>93</spage><epage>103</epage><pages>93-103</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>Acute lymphoblastic leukemia of T cell lineage (T-ALL) is an aggressive malignant disease which accounts for 15 % of childhood ALL. T(11;14) is the more frequent chromosomal abnormality in childhood T-ALL, but its prognostic value remained controversial. Our aim was to analyze the outcome of childhood T-ALL with t(11;14) to know if the presence of this translocation is associated with a poor prognosis. We conducted a retrospective study from a series of 20 patients with t(11;14), treated in two consecutive trials from the European Organization for Research and Treatment of Cancer Children Leukemia Group over a 19-year period from 1989 to 2008. There were no significant differences between the 2 consecutive groups of patients with t(11;14) regarding the clinical and biological features at diagnosis. Among 19 patients who reached complete remission, 9 patients relapsed. We noticed 7 deaths all relapse- or failure-related. In the 58881 study, a presence of t(11;14) was associated with a poor outcome with an event-free survival at 5 years at 22.2 % versus 65.1 % for the non-t(11;14) T-ALL (
p
= 0.0004). In the more recent protocol, the outcome of T-ALL with t(11;14) reached that of non-t(11;14) T-ALL with an event-free survival at 5 years at 65.5 versus 74.9 % (
p
= 0.93). The presence of t(11;14) appeared as a poor prognostic feature in the 58881 trial whereas this abnormality no longer affected the outcome in the 58951 study. This difference is probably explained by the more intensive chemotherapy in the latest trial.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26455579</pmid><doi>10.1007/s00277-015-2515-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4693-1671</orcidid><orcidid>https://orcid.org/0000-0002-3257-0302</orcidid><orcidid>https://orcid.org/0000-0002-9920-8359</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-5555 |
| ispartof | Annals of hematology, 2016-01, Vol.95 (1), p.93-103 |
| issn | 0939-5555 1432-0584 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01482631v1 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Child Child, Preschool Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 14 - genetics Cohort Studies Economics and Finance Female Hematology Human health and pathology Humanities and Social Sciences Humans Life Sciences Male Medicine Medicine & Public Health Oncology Original Article Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality Prospective Studies Psychiatrics and mental health Psychology Retrospective Studies Santé publique et épidémiologie Survival Rate - trends Translocation, Genetic - genetics Treatment Outcome |
| title | Different outcome of T cell acute lymphoblastic leukemia with translocation t(11;14) treated in two consecutive children leukemia group EORTC trials |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T19%3A56%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20outcome%20of%20T%20cell%20acute%20lymphoblastic%20leukemia%20with%20translocation%20t(11;14)%20treated%20in%20two%20consecutive%20children%20leukemia%20group%20EORTC%20trials&rft.jtitle=Annals%20of%20hematology&rft.au=Simon,%20Pauline&rft.aucorp=Children%E2%80%99s%20Leukemia%20Group%20(CLG)%20of%20the%20European%20Organisation%20for%20Research%20and%20Treatment%20of%20Cancer%20(EORTC)&rft.date=2016-01-01&rft.volume=95&rft.issue=1&rft.spage=93&rft.epage=103&rft.pages=93-103&rft.issn=0939-5555&rft.eissn=1432-0584&rft_id=info:doi/10.1007/s00277-015-2515-8&rft_dat=%3Cproquest_hal_p%3E3911267701%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1753184053&rft_id=info:pmid/26455579&rfr_iscdi=true |