The effects of caffeic, coumaric and ferulic acids on proliferation, superoxide production, adhesion and migration of human tumor cells in vitro
Reactive oxygen species are well-known mediators of various biological responses. In this study, we examined the effect of three phenolic acids, caffeic, coumaric and ferulic acids, on superoxide anion production, adhesion and migration of human lung (A549) and colon adenocarcinoma (HT29-D4) cancer...
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| Veröffentlicht in: | European journal of pharmacology 2015-11, Vol.766, p.99-105 |
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| creator | Nasr Bouzaiene, Nouha Kilani Jaziri, Soumaya Kovacic, Hervé Chekir-Ghedira, Leila Ghedira, Kamel Luis, José |
| description | Reactive oxygen species are well-known mediators of various biological responses. In this study, we examined the effect of three phenolic acids, caffeic, coumaric and ferulic acids, on superoxide anion production, adhesion and migration of human lung (A549) and colon adenocarcinoma (HT29-D4) cancer cell lines. Proliferation of both tumor cells was inhibited by phenolic acids. Caffeic, coumaric and ferulic acids also significantly inhibited superoxide production in A549 and HT29-D4 cells. Superoxide anion production decreased by 92% and 77% at the highest tested concentration (200µM) of caffeic acid in A549 and HT29-D4 cell lines respectively. Furthermore, A549 and HT29-D4 cell adhesion was reduced by 77.9% and 79.8% respectively at the higher tested concentration of ferulic acid (200µM). Migration assay performed towards A549 cell line, revealed that tested compounds reduced significantly cell migration. At the highest concentration tested (200µM), the covered surface was 7.7%, 9.5% and 35% for caffeic, coumaric or ferulic acids, respectively. These results demonstrate that caffeic, coumaric and ferulic acids may participate as active ingredients in anticancer agents against lung and colon cancer development, at adhesion and migration steps of tumor progression. |
| doi_str_mv | 10.1016/j.ejphar.2015.09.044 |
| format | Article |
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In this study, we examined the effect of three phenolic acids, caffeic, coumaric and ferulic acids, on superoxide anion production, adhesion and migration of human lung (A549) and colon adenocarcinoma (HT29-D4) cancer cell lines. Proliferation of both tumor cells was inhibited by phenolic acids. Caffeic, coumaric and ferulic acids also significantly inhibited superoxide production in A549 and HT29-D4 cells. Superoxide anion production decreased by 92% and 77% at the highest tested concentration (200µM) of caffeic acid in A549 and HT29-D4 cell lines respectively. Furthermore, A549 and HT29-D4 cell adhesion was reduced by 77.9% and 79.8% respectively at the higher tested concentration of ferulic acid (200µM). Migration assay performed towards A549 cell line, revealed that tested compounds reduced significantly cell migration. At the highest concentration tested (200µM), the covered surface was 7.7%, 9.5% and 35% for caffeic, coumaric or ferulic acids, respectively. These results demonstrate that caffeic, coumaric and ferulic acids may participate as active ingredients in anticancer agents against lung and colon cancer development, at adhesion and migration steps of tumor progression.</description><identifier>ISSN: 0014-2999</identifier><identifier>ISSN: 1879-0712</identifier><identifier>EISSN: 1879-0712</identifier><identifier>EISSN: 0014-2999</identifier><identifier>DOI: 10.1016/j.ejphar.2015.09.044</identifier><identifier>PMID: 26432689</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adhesion ; Antineoplastic Agents - pharmacology ; Antioxidants - pharmacology ; Caffeic Acids - pharmacology ; Cancer ; Cell Adhesion - drug effects ; Cell Line, Tumor ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Coumaric Acids - pharmacology ; Food and Nutrition ; Humans ; Life Sciences ; Migration ; Phenolic acids ; Reactive oxygen species ; Superoxides - metabolism ; Wound Healing - drug effects</subject><ispartof>European journal of pharmacology, 2015-11, Vol.766, p.99-105</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-1e04c6e64a6321d7fd5ddb8e6e1426e09d00d5dfdb981dcf1e185ea9e8769b783</citedby><cites>FETCH-LOGICAL-c3574-1e04c6e64a6321d7fd5ddb8e6e1426e09d00d5dfdb981dcf1e185ea9e8769b783</cites><orcidid>0000-0001-7419-6016 ; 0000-0001-6509-4210</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2015.09.044$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26432689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-01481645$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasr Bouzaiene, Nouha</creatorcontrib><creatorcontrib>Kilani Jaziri, Soumaya</creatorcontrib><creatorcontrib>Kovacic, Hervé</creatorcontrib><creatorcontrib>Chekir-Ghedira, Leila</creatorcontrib><creatorcontrib>Ghedira, Kamel</creatorcontrib><creatorcontrib>Luis, José</creatorcontrib><title>The effects of caffeic, coumaric and ferulic acids on proliferation, superoxide production, adhesion and migration of human tumor cells in vitro</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Reactive oxygen species are well-known mediators of various biological responses. In this study, we examined the effect of three phenolic acids, caffeic, coumaric and ferulic acids, on superoxide anion production, adhesion and migration of human lung (A549) and colon adenocarcinoma (HT29-D4) cancer cell lines. Proliferation of both tumor cells was inhibited by phenolic acids. Caffeic, coumaric and ferulic acids also significantly inhibited superoxide production in A549 and HT29-D4 cells. Superoxide anion production decreased by 92% and 77% at the highest tested concentration (200µM) of caffeic acid in A549 and HT29-D4 cell lines respectively. Furthermore, A549 and HT29-D4 cell adhesion was reduced by 77.9% and 79.8% respectively at the higher tested concentration of ferulic acid (200µM). Migration assay performed towards A549 cell line, revealed that tested compounds reduced significantly cell migration. At the highest concentration tested (200µM), the covered surface was 7.7%, 9.5% and 35% for caffeic, coumaric or ferulic acids, respectively. These results demonstrate that caffeic, coumaric and ferulic acids may participate as active ingredients in anticancer agents against lung and colon cancer development, at adhesion and migration steps of tumor progression.</description><subject>Adhesion</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Caffeic Acids - pharmacology</subject><subject>Cancer</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Coumaric Acids - pharmacology</subject><subject>Food and Nutrition</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Migration</subject><subject>Phenolic acids</subject><subject>Reactive oxygen species</subject><subject>Superoxides - metabolism</subject><subject>Wound Healing - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><issn>1879-0712</issn><issn>0014-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu3CAQhlHVqNmmfYOq4thIsQssBnOpFEVJE2mlXtIzYmGoWdlmC_aqfYs-cnGc5tgTo5-Pf5j5EfpASU0JFZ8PNRyOnUk1I7SpiaoJ56_QhrZSVURS9hptCKG8Ykqpc_Q25wMhpFGseYPOmeBbJlq1QX8eO8DgPdgp4-ixNaUO9grbOA8mBYvN6LCHNPdLbYMr2IiPKfahqGYKcbzCeT5Cir-Cg-XGzXaVjesgl-rJYwg_Vnxp0xXzEU_zEBO20PcZhxGfwpTiO3TmTZ_h_fN5gb7f3T7e3Fe7b18fbq53ld02klcUCLcCBDdiy6iT3jXO7VsQQDkTQJQjpEje7VVLnfUUaNuAUdBKofay3V6gy9W3M70-plCG_a2jCfr-eqcXreyupYI3J1rYTytbhvs5Q570EPLybTNCnLOmkkmlqJSyoHxFbYo5J_Av3pToJTd90GtueslNE6VLbuXZx-cO834A9_LoX1AF-LICUHZyCpB0tgFGCy6kkp12Mfy_w188Nq0h</recordid><startdate>20151105</startdate><enddate>20151105</enddate><creator>Nasr Bouzaiene, Nouha</creator><creator>Kilani Jaziri, Soumaya</creator><creator>Kovacic, Hervé</creator><creator>Chekir-Ghedira, Leila</creator><creator>Ghedira, Kamel</creator><creator>Luis, José</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-7419-6016</orcidid><orcidid>https://orcid.org/0000-0001-6509-4210</orcidid></search><sort><creationdate>20151105</creationdate><title>The effects of caffeic, coumaric and ferulic acids on proliferation, superoxide production, adhesion and migration of human tumor cells in vitro</title><author>Nasr Bouzaiene, Nouha ; Kilani Jaziri, Soumaya ; Kovacic, Hervé ; Chekir-Ghedira, Leila ; Ghedira, Kamel ; Luis, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-1e04c6e64a6321d7fd5ddb8e6e1426e09d00d5dfdb981dcf1e185ea9e8769b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adhesion</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Caffeic Acids - pharmacology</topic><topic>Cancer</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Coumaric Acids - pharmacology</topic><topic>Food and Nutrition</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Migration</topic><topic>Phenolic acids</topic><topic>Reactive oxygen species</topic><topic>Superoxides - metabolism</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasr Bouzaiene, Nouha</creatorcontrib><creatorcontrib>Kilani Jaziri, Soumaya</creatorcontrib><creatorcontrib>Kovacic, Hervé</creatorcontrib><creatorcontrib>Chekir-Ghedira, Leila</creatorcontrib><creatorcontrib>Ghedira, Kamel</creatorcontrib><creatorcontrib>Luis, José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasr Bouzaiene, Nouha</au><au>Kilani Jaziri, Soumaya</au><au>Kovacic, Hervé</au><au>Chekir-Ghedira, Leila</au><au>Ghedira, Kamel</au><au>Luis, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of caffeic, coumaric and ferulic acids on proliferation, superoxide production, adhesion and migration of human tumor cells in vitro</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2015-11-05</date><risdate>2015</risdate><volume>766</volume><spage>99</spage><epage>105</epage><pages>99-105</pages><issn>0014-2999</issn><issn>1879-0712</issn><eissn>1879-0712</eissn><eissn>0014-2999</eissn><abstract>Reactive oxygen species are well-known mediators of various biological responses. In this study, we examined the effect of three phenolic acids, caffeic, coumaric and ferulic acids, on superoxide anion production, adhesion and migration of human lung (A549) and colon adenocarcinoma (HT29-D4) cancer cell lines. Proliferation of both tumor cells was inhibited by phenolic acids. Caffeic, coumaric and ferulic acids also significantly inhibited superoxide production in A549 and HT29-D4 cells. Superoxide anion production decreased by 92% and 77% at the highest tested concentration (200µM) of caffeic acid in A549 and HT29-D4 cell lines respectively. Furthermore, A549 and HT29-D4 cell adhesion was reduced by 77.9% and 79.8% respectively at the higher tested concentration of ferulic acid (200µM). Migration assay performed towards A549 cell line, revealed that tested compounds reduced significantly cell migration. At the highest concentration tested (200µM), the covered surface was 7.7%, 9.5% and 35% for caffeic, coumaric or ferulic acids, respectively. These results demonstrate that caffeic, coumaric and ferulic acids may participate as active ingredients in anticancer agents against lung and colon cancer development, at adhesion and migration steps of tumor progression.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26432689</pmid><doi>10.1016/j.ejphar.2015.09.044</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7419-6016</orcidid><orcidid>https://orcid.org/0000-0001-6509-4210</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adhesion Antineoplastic Agents - pharmacology Antioxidants - pharmacology Caffeic Acids - pharmacology Cancer Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Coumaric Acids - pharmacology Food and Nutrition Humans Life Sciences Migration Phenolic acids Reactive oxygen species Superoxides - metabolism Wound Healing - drug effects |
| title | The effects of caffeic, coumaric and ferulic acids on proliferation, superoxide production, adhesion and migration of human tumor cells in vitro |
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