Behavioral and neurochemical effects of dietary methyl donor deficiency combined with unpredictable chronic mild stress in rats

•Methyl donor deficient diet caused disinhibiton.•Chronic stress exacerbated methyl donor deficiency effects on locomotors activity.•Hyperhomocysteinemia may contribute to monoaminergic and behavioral disturbances. Methyl donor deficiencies and chronic stress cause depression independently, but thei...

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Veröffentlicht in:	Behavioural brain research 2014-03, Vol.261, p.8-16
Hauptverfasser:	Javelot, H., Messaoudi, M., Jacquelin, C., Bisson, J.F., Rozan, P., Nejdi, A., Lazarus, C., Cassel, J.C., Strazielle, C., Lalonde, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Analysis of Variance Animals B-vitamin Behavior Biogenic Amines - metabolism Biological and medical sciences Brain - metabolism Choline Deficiency - complications Choline Deficiency - metabolism Chronic Disease Chronic mild stress Corticosterone - blood Depression Diet Disease Models, Animal Exploratory Behavior - physiology Folic Acid Deficiency - complications Folic Acid Deficiency - metabolism Fundamental and applied biological sciences. Psychology Homocysteine - blood Immunology Life Sciences Maze Learning - physiology Medical sciences Methyl donors Microbiology and Parasitology Mood disorders Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rat Rats Rats, Wistar Spinal Cord - metabolism Stress, Psychological - blood Stress, Psychological - etiology Stress, Psychological - pathology Swimming - psychology Vertebrates: nervous system and sense organs
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