Krox20 heterozygous mice: A model of aortic regurgitation associated with decreased expression of fibrillar collagen genes

Summary Background The mechanism involved in the onset of aortic valve (AoV) disease remains unclear despite its poor prognosis and frequency. Recently, we reported that Krox20 ( EGR2 in humans) is involved in AoV development and dysfunction. Aim Analyze Krox20 heterozygous mice ( Krox20 +/− ) to di...

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Veröffentlicht in:	Archives of cardiovascular diseases 2016-03, Vol.109 (3), p.188-198
Hauptverfasser:	Théron, Alexis, Odelin, Gaëlle, Faure, Emilie, Avierinos, Jean-François, Zaffran, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Valve - diagnostic imaging Aortic Valve - metabolism Aortic Valve - physiopathology Aortic Valve Insufficiency - diagnostic imaging Aortic Valve Insufficiency - genetics Aortic Valve Insufficiency - metabolism Aortic Valve Insufficiency - physiopathology Aortic valve regurgitation Biochemistry, Molecular Biology Cardiovascular Case-Control Studies Collagen Type I - genetics Collagen Type I - metabolism Collagens Collagènes Disease Models, Animal Down-Regulation Early Growth Response Protein 2 - deficiency Early Growth Response Protein 2 - genetics Early Growth Response Protein 2 - metabolism Echocardiography, Doppler Extracellular matrix Genetic Predisposition to Disease Genomics Heart valve Heterozygote Humans Internal Medicine Krox20 Life Sciences Matrice extracellulaire Mice, Inbred C57BL Mice, Knockout Phenotype RNA, Messenger - genetics RNA, Messenger - metabolism Régurgitation aortique Severity of Illness Index Souris Transcription, Genetic Valve cardiaque
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