Cognitive processing impairments in a supra-second temporal discrimination task in rats with cerebellar lesion
The role of interpositus nuclei (IN) in timing in the sub-second range is well supported in eyeblink conditioning studies. Timing impairments shown in the seconds range in patients with intermediate cerebellar lesion, and known intermediate cerebellar cortex projection to IN raise the question of a...
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| Veröffentlicht in: | Neurobiology of learning and memory 2009-03, Vol.91 (3), p.250-259 |
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| creator | Callu, Delphine Massioui, Nicole El Dutrieux, Gérard Brown, Bruce L. Doyere, Valérie |
| description | The role of interpositus nuclei (IN) in timing in the sub-second range is well supported in eyeblink conditioning studies. Timing impairments shown in the seconds range in patients with intermediate cerebellar lesion, and known intermediate cerebellar cortex projection to IN raise the question of a possible involvement of IN in timing in the supra-second range as well. To address this question, we tested rats (Sprague-Dawley) given bilateral lesions of IN with Colchicine in a 2- vs. 8-s temporal discrimination task, followed by three daily sessions of a temporal bisection tests with five added intermediate non-reinforced durations. IN lesioned rats showed normal acquisition of the temporal discrimination, but a transient impairment of temporal sensitivity during the bisection tests. In addition, their response latencies suggested a different behavioral strategy from that of control animals. Our results indicate that the IN of the cerebellum may not be critically involved in temporal processing in the 2–8
s range, but may play a role in the cognitive processes that access temporal information in the mediation of choice behavior. |
| doi_str_mv | 10.1016/j.nlm.2008.12.002 |
| format | Article |
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s range, but may play a role in the cognitive processes that access temporal information in the mediation of choice behavior.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Auditory Perception</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Bisection</subject><subject>Brain damage</subject><subject>Cerebellar Diseases</subject><subject>Cerebellar Diseases - chemically induced</subject><subject>Cerebellar Diseases - pathology</subject><subject>Cerebellar Diseases - physiopathology</subject><subject>Cerebellum</subject><subject>Cerebellum - pathology</subject><subject>Cerebellum - physiopathology</subject><subject>Choice Behavior</subject><subject>Cognition Disorders</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognitive ability</subject><subject>Cognitive Sciences</subject><subject>Colchicine</subject><subject>Discrimination Learning</subject><subject>Discrimination Learning - physiology</subject><subject>Executive dysfunction</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Habit</subject><subject>Interpositus nuclei</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Psychology and behavior</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance</subject><subject>Random Allocation</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reaction Time</subject><subject>Reflexes</subject><subject>Reinforcement (Psychology)</subject><subject>Rodents</subject><subject>Time Perception</subject><subject>Time Perception - physiology</subject><subject>Timing</subject><issn>1074-7427</issn><issn>1095-9564</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEoh_wA7ggCwkkDgkexx-JOFUrSiutxKU9W15n0npJ7GAni_j3ONpVkTj05JH1vDPvzFsU74BWQEF-2Vd-GCtGaVMBqyhlL4pzoK0oWyH5y7VWvFScqbPiIqU9pQCibV4XZ9BCFgk4L_wmPHg3uwOSKQaLKTn_QNw4GRdH9HMizhND0jJFUya0wXdkxnEK0Qykc8lGNzpvZhc8mU36ueLRZNlvNz8SixF3OAwmkgFTZt4Ur3ozJHx7ei-L--tvd5ubcvvj--3maltaruq55KKWtKUq-2xYb61hVvag0HatFE3X16axdcfVrm87arkQQuaCIdoeldphfVl8PvZ9NIOeskcT_-hgnL652ur1jwKXikt2gMx-OrL5AL8WTLMe816ra49hSZpRTmXLWAY__AfuwxJ93kOzWoIABTRDcIRsDClF7J_GA9Vranqvc2p6TU0D0zm1rHl_arzsRuz-KU4xZeDjCTDJmqGPxluXnjgGTAmQdea-HjnMtz04jDpZh95i5yLaWXfBPWPjL9intWs</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Callu, Delphine</creator><creator>Massioui, Nicole El</creator><creator>Dutrieux, Gérard</creator><creator>Brown, Bruce L.</creator><creator>Doyere, Valérie</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-3851-669X</orcidid></search><sort><creationdate>20090301</creationdate><title>Cognitive processing impairments in a supra-second temporal discrimination task in rats with cerebellar lesion</title><author>Callu, Delphine ; Massioui, Nicole El ; Dutrieux, Gérard ; Brown, Bruce L. ; Doyere, Valérie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-4536090719182fcca2c6f17ecd9658df3a8c3d47bf9d0c455569d02eecfe77be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Auditory Perception</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Bisection</topic><topic>Brain damage</topic><topic>Cerebellar Diseases</topic><topic>Cerebellar Diseases - chemically induced</topic><topic>Cerebellar Diseases - pathology</topic><topic>Cerebellar Diseases - physiopathology</topic><topic>Cerebellum</topic><topic>Cerebellum - pathology</topic><topic>Cerebellum - physiopathology</topic><topic>Choice Behavior</topic><topic>Cognition Disorders</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognitive ability</topic><topic>Cognitive Sciences</topic><topic>Colchicine</topic><topic>Discrimination Learning</topic><topic>Discrimination Learning - physiology</topic><topic>Executive dysfunction</topic><topic>Fundamental and applied biological sciences. 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Psychophysiology</topic><topic>Psychomotor Performance</topic><topic>Random Allocation</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reaction Time</topic><topic>Reflexes</topic><topic>Reinforcement (Psychology)</topic><topic>Rodents</topic><topic>Time Perception</topic><topic>Time Perception - physiology</topic><topic>Timing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Callu, Delphine</creatorcontrib><creatorcontrib>Massioui, Nicole El</creatorcontrib><creatorcontrib>Dutrieux, Gérard</creatorcontrib><creatorcontrib>Brown, Bruce L.</creatorcontrib><creatorcontrib>Doyere, Valérie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neurobiology of learning and memory</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Callu, Delphine</au><au>Massioui, Nicole El</au><au>Dutrieux, Gérard</au><au>Brown, Bruce L.</au><au>Doyere, Valérie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive processing impairments in a supra-second temporal discrimination task in rats with cerebellar lesion</atitle><jtitle>Neurobiology of learning and memory</jtitle><addtitle>Neurobiol Learn Mem</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>91</volume><issue>3</issue><spage>250</spage><epage>259</epage><pages>250-259</pages><issn>1074-7427</issn><eissn>1095-9564</eissn><abstract>The role of interpositus nuclei (IN) in timing in the sub-second range is well supported in eyeblink conditioning studies. Timing impairments shown in the seconds range in patients with intermediate cerebellar lesion, and known intermediate cerebellar cortex projection to IN raise the question of a possible involvement of IN in timing in the supra-second range as well. To address this question, we tested rats (Sprague-Dawley) given bilateral lesions of IN with Colchicine in a 2- vs. 8-s temporal discrimination task, followed by three daily sessions of a temporal bisection tests with five added intermediate non-reinforced durations. IN lesioned rats showed normal acquisition of the temporal discrimination, but a transient impairment of temporal sensitivity during the bisection tests. In addition, their response latencies suggested a different behavioral strategy from that of control animals. Our results indicate that the IN of the cerebellum may not be critically involved in temporal processing in the 2–8
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| subjects | Analysis of Variance Animals Auditory Perception Behavioral psychophysiology Biological and medical sciences Bisection Brain damage Cerebellar Diseases Cerebellar Diseases - chemically induced Cerebellar Diseases - pathology Cerebellar Diseases - physiopathology Cerebellum Cerebellum - pathology Cerebellum - physiopathology Choice Behavior Cognition Disorders Cognition Disorders - physiopathology Cognitive ability Cognitive Sciences Colchicine Discrimination Learning Discrimination Learning - physiology Executive dysfunction Fundamental and applied biological sciences. Psychology Habit Interpositus nuclei Life Sciences Male Neurobiology Neurology Neurons and Cognition Psychology and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance Random Allocation Rat Rats Rats, Sprague-Dawley Reaction Time Reflexes Reinforcement (Psychology) Rodents Time Perception Time Perception - physiology Timing |
| title | Cognitive processing impairments in a supra-second temporal discrimination task in rats with cerebellar lesion |
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