Multivariate statistical process control (MSPC) using Raman spectroscopy for in-line culture cell monitoring considering time-varying batches synchronized with correlation optimized warping (COW)

Multivariate statistical process control (MSPC) is increasingly popular as the challenge provided by large multivariate datasets from analytical instruments such as Raman spectroscopy for the monitoring of complex cell cultures in the biopharmaceutical industry. However, Raman spectroscopy for in-li...

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Veröffentlicht in:	Analytica chimica acta 2017-02, Vol.952, p.9-17
Hauptverfasser:	Liu, Ya-Juan, André, Silvère, Saint Cristau, Lydia, Lagresle, Sylvain, Hannas, Zahia, Calvosa, Éric, Devos, Olivier, Duponchel, Ludovic
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopharmaceuticals Biotechnology Cell culture Cell Culture Techniques Charts Chemical Sciences Chemometrics CHO Cells Contamination Control charts Correlation optimized warping (COW) Cricetulus Data processing Datasets Environmental monitoring Models, Statistical Monitoring instruments Multi-way principal component analysis (MPCA) Multivariate Analysis Multivariate statistical process control (MSPC) or physical chemistry Principal Component Analysis Principal components analysis Process control Process controls Raman spectroscopy Spectroscopic analysis Spectroscopy Spectrum analysis Spectrum Analysis, Raman Statistical process control Statistics Theoretical and Time synchronization Warping
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