One-pot Crabbé homologation-radical cascade cyclisation with memory of chirality

One-pot Crabbé homologation-radical cascade cyclisation with memory of chirality

The tandem Crabbé homologation-radical rearrangement of terminal enediynes leads, in a one-pot procedure, to the enantioselective synthesis of six- and seven-membered ring α-aminoesters bearing a quaternary stereocenter based on the phenomenon of memory of chirality.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (19), p.2549-2551
Hauptverfasser: Mondal, Shovan, Nechab, Malek, Vanthuyne, Nicolas, Bertrand, Michèle P
Format: Artikel
Sprache:eng
Schlagworte:
Bearing
Cascades
Chemical Sciences
Chirality
Enediynes
Homology
Rings (mathematics)
Synthesis
Terminals
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Beschreibung
Zusammenfassung:The tandem Crabbé homologation-radical rearrangement of terminal enediynes leads, in a one-pot procedure, to the enantioselective synthesis of six- and seven-membered ring α-aminoesters bearing a quaternary stereocenter based on the phenomenon of memory of chirality.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc17830c