Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial

Summary Background Chikungunya is an emerging arthropod-borne disease that has spread from tropical endemic areas to more temperate climates of the USA and Europe. However, no specific treatment or preventive measure is yet available. We aimed to investigate the immunogenicity and safety of a live r...

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Veröffentlicht in:	The Lancet infectious diseases 2015-05, Vol.15 (5), p.519-527
Hauptverfasser:	Ramsauer, Katrin, PhD, Schwameis, Michael, MD, Firbas, Christa, MD, Müllner, Matthias, PhD, Putnak, Robert J, PhD, Thomas, Stephen J, MD, Desprès, Philippe, Tauber, Erich, MD, Jilma, Bernd, Dr, Tangy, Frederic, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Neutralizing - biosynthesis Antibodies, Neutralizing - blood Antibodies, Viral - biosynthesis Antibodies, Viral - blood Antigens, Viral - administration & dosage Antigens, Viral - immunology Biomedical research Chikungunya Fever - immunology Chikungunya Fever - prevention & control Chikungunya Fever - virology Chikungunya virus - genetics Chikungunya virus - immunology Colleges & universities Double-Blind Method Drug Administration Schedule Female Healthy Volunteers Hepatitis HIV Human immunodeficiency virus Humans Immunization Immunogenicity Infections Infectious Disease Infectious diseases Life Sciences Male Measles Measles virus - genetics Measles virus - immunology Measles-Mumps-Rubella Vaccine - administration & dosage Measles-Mumps-Rubella Vaccine - immunology Middle Aged Safety Vaccines Vaccines, Synthetic Vector-borne diseases Viral Vaccines - administration & dosage Viral Vaccines - immunology
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