A preliminary study of computer assisted evaluation of congenital tracheal stenosis: A new tool for surgical decision-making
Abstract Objective Congenital tracheal stenosis is a rare but severe condition with tracheal narrowing. There is no absolute correlation between luminal diameter and prognosis, and therapeutic decisions are difficult for intermediate cases. The aim of this study was to develop a dynamic model of the...
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| Veröffentlicht in: | International journal of pediatric otorhinolaryngology 2012-11, Vol.76 (11), p.1552-1557 |
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| container_title | International journal of pediatric otorhinolaryngology |
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| creator | Mimouni-Benabu, Olivia Meister, Lionel Giordano, Jérôme Fayoux, Pierre Loundon, Natalie Triglia, Jean Michel Nicollas, Richard |
| description | Abstract Objective Congenital tracheal stenosis is a rare but severe condition with tracheal narrowing. There is no absolute correlation between luminal diameter and prognosis, and therapeutic decisions are difficult for intermediate cases. The aim of this study was to develop a dynamic model of the ventilatory consequences of congenital tracheal stenosis using computational fluid dynamics. Methods In 8 children with congenital tracheal stenosis and 1 healthy child, 3-dimensional geometries of the trachea were constructed with computed tomography images and specialized software (ITK-SNAP). Airflow simulations were performed for each geometry using 2 physiologic inhalation flow rates under steady and laminar flow conditions. Flow velocity, static and total airway pressure, and pressure drop across the entire trachea were determined. Results In the patients with congenital tracheal stenosis, the pressure drop from the tracheal inlet to outlet, at flow rate 3 L/min, ranged from 14 to 430 Pa; the pressure drop at flow rate 7.3 L/min ranged from 60 to 1825 Pa. The pressure drop enabled a classification based on the severity of stenosis. The classification based on pressure drop was retrospectively consistent with the classification based on clinical data from the patients. Conclusions Simulations with computational fluid dynamics may provide an objective method to evaluate the severity of the symptoms in patients with congenital tracheal stenosis and may help guide treatment. |
| doi_str_mv | 10.1016/j.ijporl.2012.07.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01446838v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165587612003953</els_id><sourcerecordid>1114696201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-f3791c79eb914c02d943ed54e01829786627e99669d03cd9f420013beafc2a633</originalsourceid><addsrcrecordid>eNqFkk9v1DAQxSMEotvCN0DIRzgk-F_smAPSqoIWaSUOwNnyOpOt08Re7GSrlfjwOErpgQsnW_Zv3mjem6J4Q3BFMBEf-sr1xxCHimJCKywrjNWzYkMaScuGC_682GSsLutGioviMqUeYyJxXb8sLihtJK8V2RS_t-gYYXCj8yaeUZrm9oxCh2wYj_MEEZmUXJqgRXAyw2wmF_z67w_g3WQGNEVj7yBfMuZDpj-iLfLwgKYQBtSFiNIcD85mogXrUlYoR3Pv_OFV8aIzQ4LXj-dV8fPL5x_Xt-Xu283X6-2utDWRU9kxqYiVCvaKcItpqziDtuaASUOVbISgEpQSQrWY2VZ1nOZR2R5MZ6kRjF0V71fdOzPoY3RjHlUH4_TtdqeXN0w4Fw1rTiSz71b2GMOvGdKkR5csDIPxEOakCSFcKJFNzyhfURtDShG6J22C9ZKR7vWakV4y0ljqnFEue_vYYd6P0D4V_Q0lA59WALInJwdRJ-vAW2hdBDvpNrj_dfhXwA7OLwncwxlSH-bos9-a6JRr9PdlT5Y1Idk3pmrG_gAqeroZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1114696201</pqid></control><display><type>article</type><title>A preliminary study of computer assisted evaluation of congenital tracheal stenosis: A new tool for surgical decision-making</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mimouni-Benabu, Olivia ; Meister, Lionel ; Giordano, Jérôme ; Fayoux, Pierre ; Loundon, Natalie ; Triglia, Jean Michel ; Nicollas, Richard</creator><creatorcontrib>Mimouni-Benabu, Olivia ; Meister, Lionel ; Giordano, Jérôme ; Fayoux, Pierre ; Loundon, Natalie ; Triglia, Jean Michel ; Nicollas, Richard</creatorcontrib><description>Abstract Objective Congenital tracheal stenosis is a rare but severe condition with tracheal narrowing. There is no absolute correlation between luminal diameter and prognosis, and therapeutic decisions are difficult for intermediate cases. The aim of this study was to develop a dynamic model of the ventilatory consequences of congenital tracheal stenosis using computational fluid dynamics. Methods In 8 children with congenital tracheal stenosis and 1 healthy child, 3-dimensional geometries of the trachea were constructed with computed tomography images and specialized software (ITK-SNAP). Airflow simulations were performed for each geometry using 2 physiologic inhalation flow rates under steady and laminar flow conditions. Flow velocity, static and total airway pressure, and pressure drop across the entire trachea were determined. Results In the patients with congenital tracheal stenosis, the pressure drop from the tracheal inlet to outlet, at flow rate 3 L/min, ranged from 14 to 430 Pa; the pressure drop at flow rate 7.3 L/min ranged from 60 to 1825 Pa. The pressure drop enabled a classification based on the severity of stenosis. The classification based on pressure drop was retrospectively consistent with the classification based on clinical data from the patients. Conclusions Simulations with computational fluid dynamics may provide an objective method to evaluate the severity of the symptoms in patients with congenital tracheal stenosis and may help guide treatment.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/j.ijporl.2012.07.009</identifier><identifier>PMID: 22874591</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Airflow ; Biomechanics ; Child, Preschool ; Computational fluid dynamics ; Computer Simulation ; Decision Making ; Engineering Sciences ; Fluid mechanics ; Humans ; Hydrodynamics ; Image Processing, Computer-Assisted ; Infant ; Infant, Newborn ; Mechanics ; Models, Biological ; Otolaryngology ; Pediatrics ; Physics ; Pressure ; Reactive fluid environment ; Respiratory Mechanics - physiology ; Retrospective Studies ; Segmentation ; Severity of Illness Index ; Software ; Tomography, X-Ray Computed ; Trachea ; Trachea - diagnostic imaging ; Trachea - physiopathology ; Tracheal Stenosis - classification ; Tracheal Stenosis - congenital ; Tracheal Stenosis - diagnostic imaging ; Tracheal Stenosis - physiopathology</subject><ispartof>International journal of pediatric otorhinolaryngology, 2012-11, Vol.76 (11), p.1552-1557</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-f3791c79eb914c02d943ed54e01829786627e99669d03cd9f420013beafc2a633</citedby><cites>FETCH-LOGICAL-c517t-f3791c79eb914c02d943ed54e01829786627e99669d03cd9f420013beafc2a633</cites><orcidid>0000-0002-2355-0684</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165587612003953$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22874591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01446838$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Mimouni-Benabu, Olivia</creatorcontrib><creatorcontrib>Meister, Lionel</creatorcontrib><creatorcontrib>Giordano, Jérôme</creatorcontrib><creatorcontrib>Fayoux, Pierre</creatorcontrib><creatorcontrib>Loundon, Natalie</creatorcontrib><creatorcontrib>Triglia, Jean Michel</creatorcontrib><creatorcontrib>Nicollas, Richard</creatorcontrib><title>A preliminary study of computer assisted evaluation of congenital tracheal stenosis: A new tool for surgical decision-making</title><title>International journal of pediatric otorhinolaryngology</title><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><description>Abstract Objective Congenital tracheal stenosis is a rare but severe condition with tracheal narrowing. There is no absolute correlation between luminal diameter and prognosis, and therapeutic decisions are difficult for intermediate cases. The aim of this study was to develop a dynamic model of the ventilatory consequences of congenital tracheal stenosis using computational fluid dynamics. Methods In 8 children with congenital tracheal stenosis and 1 healthy child, 3-dimensional geometries of the trachea were constructed with computed tomography images and specialized software (ITK-SNAP). Airflow simulations were performed for each geometry using 2 physiologic inhalation flow rates under steady and laminar flow conditions. Flow velocity, static and total airway pressure, and pressure drop across the entire trachea were determined. Results In the patients with congenital tracheal stenosis, the pressure drop from the tracheal inlet to outlet, at flow rate 3 L/min, ranged from 14 to 430 Pa; the pressure drop at flow rate 7.3 L/min ranged from 60 to 1825 Pa. The pressure drop enabled a classification based on the severity of stenosis. The classification based on pressure drop was retrospectively consistent with the classification based on clinical data from the patients. Conclusions Simulations with computational fluid dynamics may provide an objective method to evaluate the severity of the symptoms in patients with congenital tracheal stenosis and may help guide treatment.</description><subject>Airflow</subject><subject>Biomechanics</subject><subject>Child, Preschool</subject><subject>Computational fluid dynamics</subject><subject>Computer Simulation</subject><subject>Decision Making</subject><subject>Engineering Sciences</subject><subject>Fluid mechanics</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Image Processing, Computer-Assisted</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Mechanics</subject><subject>Models, Biological</subject><subject>Otolaryngology</subject><subject>Pediatrics</subject><subject>Physics</subject><subject>Pressure</subject><subject>Reactive fluid environment</subject><subject>Respiratory Mechanics - physiology</subject><subject>Retrospective Studies</subject><subject>Segmentation</subject><subject>Severity of Illness Index</subject><subject>Software</subject><subject>Tomography, X-Ray Computed</subject><subject>Trachea</subject><subject>Trachea - diagnostic imaging</subject><subject>Trachea - physiopathology</subject><subject>Tracheal Stenosis - classification</subject><subject>Tracheal Stenosis - congenital</subject><subject>Tracheal Stenosis - diagnostic imaging</subject><subject>Tracheal Stenosis - physiopathology</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxSMEotvCN0DIRzgk-F_smAPSqoIWaSUOwNnyOpOt08Re7GSrlfjwOErpgQsnW_Zv3mjem6J4Q3BFMBEf-sr1xxCHimJCKywrjNWzYkMaScuGC_682GSsLutGioviMqUeYyJxXb8sLihtJK8V2RS_t-gYYXCj8yaeUZrm9oxCh2wYj_MEEZmUXJqgRXAyw2wmF_z67w_g3WQGNEVj7yBfMuZDpj-iLfLwgKYQBtSFiNIcD85mogXrUlYoR3Pv_OFV8aIzQ4LXj-dV8fPL5x_Xt-Xu283X6-2utDWRU9kxqYiVCvaKcItpqziDtuaASUOVbISgEpQSQrWY2VZ1nOZR2R5MZ6kRjF0V71fdOzPoY3RjHlUH4_TtdqeXN0w4Fw1rTiSz71b2GMOvGdKkR5csDIPxEOakCSFcKJFNzyhfURtDShG6J22C9ZKR7vWakV4y0ljqnFEue_vYYd6P0D4V_Q0lA59WALInJwdRJ-vAW2hdBDvpNrj_dfhXwA7OLwncwxlSH-bos9-a6JRr9PdlT5Y1Idk3pmrG_gAqeroZ</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Mimouni-Benabu, Olivia</creator><creator>Meister, Lionel</creator><creator>Giordano, Jérôme</creator><creator>Fayoux, Pierre</creator><creator>Loundon, Natalie</creator><creator>Triglia, Jean Michel</creator><creator>Nicollas, Richard</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2355-0684</orcidid></search><sort><creationdate>20121101</creationdate><title>A preliminary study of computer assisted evaluation of congenital tracheal stenosis: A new tool for surgical decision-making</title><author>Mimouni-Benabu, Olivia ; Meister, Lionel ; Giordano, Jérôme ; Fayoux, Pierre ; Loundon, Natalie ; Triglia, Jean Michel ; Nicollas, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-f3791c79eb914c02d943ed54e01829786627e99669d03cd9f420013beafc2a633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Airflow</topic><topic>Biomechanics</topic><topic>Child, Preschool</topic><topic>Computational fluid dynamics</topic><topic>Computer Simulation</topic><topic>Decision Making</topic><topic>Engineering Sciences</topic><topic>Fluid mechanics</topic><topic>Humans</topic><topic>Hydrodynamics</topic><topic>Image Processing, Computer-Assisted</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Mechanics</topic><topic>Models, Biological</topic><topic>Otolaryngology</topic><topic>Pediatrics</topic><topic>Physics</topic><topic>Pressure</topic><topic>Reactive fluid environment</topic><topic>Respiratory Mechanics - physiology</topic><topic>Retrospective Studies</topic><topic>Segmentation</topic><topic>Severity of Illness Index</topic><topic>Software</topic><topic>Tomography, X-Ray Computed</topic><topic>Trachea</topic><topic>Trachea - diagnostic imaging</topic><topic>Trachea - physiopathology</topic><topic>Tracheal Stenosis - classification</topic><topic>Tracheal Stenosis - congenital</topic><topic>Tracheal Stenosis - diagnostic imaging</topic><topic>Tracheal Stenosis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mimouni-Benabu, Olivia</creatorcontrib><creatorcontrib>Meister, Lionel</creatorcontrib><creatorcontrib>Giordano, Jérôme</creatorcontrib><creatorcontrib>Fayoux, Pierre</creatorcontrib><creatorcontrib>Loundon, Natalie</creatorcontrib><creatorcontrib>Triglia, Jean Michel</creatorcontrib><creatorcontrib>Nicollas, Richard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mimouni-Benabu, Olivia</au><au>Meister, Lionel</au><au>Giordano, Jérôme</au><au>Fayoux, Pierre</au><au>Loundon, Natalie</au><au>Triglia, Jean Michel</au><au>Nicollas, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A preliminary study of computer assisted evaluation of congenital tracheal stenosis: A new tool for surgical decision-making</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>76</volume><issue>11</issue><spage>1552</spage><epage>1557</epage><pages>1552-1557</pages><issn>0165-5876</issn><eissn>1872-8464</eissn><abstract>Abstract Objective Congenital tracheal stenosis is a rare but severe condition with tracheal narrowing. There is no absolute correlation between luminal diameter and prognosis, and therapeutic decisions are difficult for intermediate cases. The aim of this study was to develop a dynamic model of the ventilatory consequences of congenital tracheal stenosis using computational fluid dynamics. Methods In 8 children with congenital tracheal stenosis and 1 healthy child, 3-dimensional geometries of the trachea were constructed with computed tomography images and specialized software (ITK-SNAP). Airflow simulations were performed for each geometry using 2 physiologic inhalation flow rates under steady and laminar flow conditions. Flow velocity, static and total airway pressure, and pressure drop across the entire trachea were determined. Results In the patients with congenital tracheal stenosis, the pressure drop from the tracheal inlet to outlet, at flow rate 3 L/min, ranged from 14 to 430 Pa; the pressure drop at flow rate 7.3 L/min ranged from 60 to 1825 Pa. The pressure drop enabled a classification based on the severity of stenosis. The classification based on pressure drop was retrospectively consistent with the classification based on clinical data from the patients. Conclusions Simulations with computational fluid dynamics may provide an objective method to evaluate the severity of the symptoms in patients with congenital tracheal stenosis and may help guide treatment.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22874591</pmid><doi>10.1016/j.ijporl.2012.07.009</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2355-0684</orcidid></addata></record> |
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| ispartof | International journal of pediatric otorhinolaryngology, 2012-11, Vol.76 (11), p.1552-1557 |
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| subjects | Airflow Biomechanics Child, Preschool Computational fluid dynamics Computer Simulation Decision Making Engineering Sciences Fluid mechanics Humans Hydrodynamics Image Processing, Computer-Assisted Infant Infant, Newborn Mechanics Models, Biological Otolaryngology Pediatrics Physics Pressure Reactive fluid environment Respiratory Mechanics - physiology Retrospective Studies Segmentation Severity of Illness Index Software Tomography, X-Ray Computed Trachea Trachea - diagnostic imaging Trachea - physiopathology Tracheal Stenosis - classification Tracheal Stenosis - congenital Tracheal Stenosis - diagnostic imaging Tracheal Stenosis - physiopathology |
| title | A preliminary study of computer assisted evaluation of congenital tracheal stenosis: A new tool for surgical decision-making |
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