Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells

Group 3 innate lymphoid cells (ILC3s) are composed of subsets that are either positive or negative for the natural cytotoxicity receptor (NCR) NKp46 (encoded by Ncr1). ILC3s are located at mucosal sites, such as in the intestine and lung, where they are exposed to billions of commensal microbes and...

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Veröffentlicht in:	Science signaling 2016-05, Vol.9 (426), p.ra46-ra46
Hauptverfasser:	Viant, Charlotte, Rankin, Lucille C, Girard-Madoux, Mathilde J H, Seillet, Cyril, Shi, Wei, Smyth, Mark J, Bartholin, Laurent, Walzer, Thierry, Huntington, Nicholas D, Vivier, Eric, Belz, Gabrielle T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - metabolism Cell Differentiation Cytokines - metabolism Female Immunity, Innate Immunology Intestines - metabolism Life Sciences Ligands Lung - metabolism Lymphocytes - cytology Male Mice Mice, Transgenic Natural Cytotoxicity Triggering Receptor 1 - metabolism Receptor, Notch1 - metabolism Signal Transduction T-Lymphocytes - cytology Transcription, Genetic Transforming Growth Factor beta1 - metabolism
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