Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells
Group 3 innate lymphoid cells (ILC3s) are composed of subsets that are either positive or negative for the natural cytotoxicity receptor (NCR) NKp46 (encoded by Ncr1). ILC3s are located at mucosal sites, such as in the intestine and lung, where they are exposed to billions of commensal microbes and...
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| Veröffentlicht in: | Science signaling 2016-05, Vol.9 (426), p.ra46-ra46 |
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| creator | Viant, Charlotte Rankin, Lucille C Girard-Madoux, Mathilde J H Seillet, Cyril Shi, Wei Smyth, Mark J Bartholin, Laurent Walzer, Thierry Huntington, Nicholas D Vivier, Eric Belz, Gabrielle T |
| description | Group 3 innate lymphoid cells (ILC3s) are composed of subsets that are either positive or negative for the natural cytotoxicity receptor (NCR) NKp46 (encoded by Ncr1). ILC3s are located at mucosal sites, such as in the intestine and lung, where they are exposed to billions of commensal microbes and potentially harmful pathogens. Together with T cells, the various ILC3 subsets maintain the balance between homeostasis and immune activation. Through genetic mapping, we identified a previously uncharacterized subset of NCR(-) ILC3s in mice that transiently express Ncr1, demonstrating previously undescribed heterogeneity within the ILC3 population. In addition, we showed that sustained Notch signaling was required for the maintenance of the NCR(+) phenotype and that the cytokine transforming growth factor-β (TGF-β) impaired the development of NCR(+) ILC3s. Thus, the plasticity of ILC3s is regulated by the balance between the opposing effects of Notch and TGF-β signaling, maintaining homeostasis in the face of continual challenges. |
| doi_str_mv | 10.1126/scisignal.aaf2176 |
| format | Article |
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Thus, the plasticity of ILC3s is regulated by the balance between the opposing effects of Notch and TGF-β signaling, maintaining homeostasis in the face of continual challenges.</description><identifier>ISSN: 1945-0877</identifier><identifier>ISSN: 1937-9145</identifier><identifier>EISSN: 1937-9145</identifier><identifier>DOI: 10.1126/scisignal.aaf2176</identifier><identifier>PMID: 27141930</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science (AAAS)</publisher><subject>Animals ; Antigens, Ly - metabolism ; Cell Differentiation ; Cytokines - metabolism ; Female ; Immunity, Innate ; Immunology ; Intestines - metabolism ; Life Sciences ; Ligands ; Lung - metabolism ; Lymphocytes - cytology ; Male ; Mice ; Mice, Transgenic ; Natural Cytotoxicity Triggering Receptor 1 - metabolism ; Receptor, Notch1 - metabolism ; Signal Transduction ; T-Lymphocytes - cytology ; Transcription, Genetic ; Transforming Growth Factor beta1 - metabolism</subject><ispartof>Science signaling, 2016-05, Vol.9 (426), p.ra46-ra46</ispartof><rights>Copyright © 2016, American Association for the Advancement of Science.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-cd3e4be980000a31c11b159f40bb1cf7f136c4ba31520e284d1f554ff85a02023</citedby><cites>FETCH-LOGICAL-c335t-cd3e4be980000a31c11b159f40bb1cf7f136c4ba31520e284d1f554ff85a02023</cites><orcidid>0000-0002-0941-8679 ; 0000-0002-5637-3223 ; 0000-0002-0857-8179 ; 0000-0001-7022-8287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,2871,2872,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27141930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01438546$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Viant, Charlotte</creatorcontrib><creatorcontrib>Rankin, Lucille C</creatorcontrib><creatorcontrib>Girard-Madoux, Mathilde J H</creatorcontrib><creatorcontrib>Seillet, Cyril</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><creatorcontrib>Smyth, Mark J</creatorcontrib><creatorcontrib>Bartholin, Laurent</creatorcontrib><creatorcontrib>Walzer, Thierry</creatorcontrib><creatorcontrib>Huntington, Nicholas D</creatorcontrib><creatorcontrib>Vivier, Eric</creatorcontrib><creatorcontrib>Belz, Gabrielle T</creatorcontrib><title>Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells</title><title>Science signaling</title><addtitle>Sci Signal</addtitle><description>Group 3 innate lymphoid cells (ILC3s) are composed of subsets that are either positive or negative for the natural cytotoxicity receptor (NCR) NKp46 (encoded by Ncr1). 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Thus, the plasticity of ILC3s is regulated by the balance between the opposing effects of Notch and TGF-β signaling, maintaining homeostasis in the face of continual challenges.</description><subject>Animals</subject><subject>Antigens, Ly - metabolism</subject><subject>Cell Differentiation</subject><subject>Cytokines - metabolism</subject><subject>Female</subject><subject>Immunity, Innate</subject><subject>Immunology</subject><subject>Intestines - metabolism</subject><subject>Life Sciences</subject><subject>Ligands</subject><subject>Lung - metabolism</subject><subject>Lymphocytes - cytology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Natural Cytotoxicity Triggering Receptor 1 - metabolism</subject><subject>Receptor, Notch1 - metabolism</subject><subject>Signal Transduction</subject><subject>T-Lymphocytes - cytology</subject><subject>Transcription, Genetic</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><issn>1945-0877</issn><issn>1937-9145</issn><issn>1937-9145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUuO1DAQhiMEYh5wADbIS1hkcPmRx3I0ghmkFmyGteU4dmLk2MF2z6hPwV04CGfCUTddG1e5vv-Xrb-q3gG-ASDNp6RsspOX7kZKQ6BtXlSX0NO27oHxl1vPeI27tr2orlL6iXEDhPSvqwvSAisgvqx-P0bpkwlxsX5CUwzPeUZGqhxi_fcPkn5E30JWM3J2KkNCZYVkQmFdQ9ok2j_ZGPyifZYOqb1OyHoU9bR3Mm9AnjVanUzZKpsPKBiUD6tGtGBeZo3cYVnnYEektHPpTfXKSJf029N5Xf348vnx7qHefb__ene7qxWlPNdqpJoNuu9wKUlBAQzAe8PwMIAyrQHaKDaUDSdYk46NYDhnxnRcYoIJva4-Hn1n6cQa7SLjQQRpxcPtTmx3GBjtOGueoLAfjuwaw6_ywSwWm7bXSq_DPglouxb3HLoNhSOqYkgpanP2Biy2zMQ5M3HKrGjen-z3w6LHs-J_SPQftfeYQw</recordid><startdate>20160503</startdate><enddate>20160503</enddate><creator>Viant, Charlotte</creator><creator>Rankin, Lucille C</creator><creator>Girard-Madoux, Mathilde J H</creator><creator>Seillet, Cyril</creator><creator>Shi, Wei</creator><creator>Smyth, Mark J</creator><creator>Bartholin, Laurent</creator><creator>Walzer, Thierry</creator><creator>Huntington, Nicholas D</creator><creator>Vivier, Eric</creator><creator>Belz, Gabrielle T</creator><general>American Association for the Advancement of Science (AAAS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0941-8679</orcidid><orcidid>https://orcid.org/0000-0002-5637-3223</orcidid><orcidid>https://orcid.org/0000-0002-0857-8179</orcidid><orcidid>https://orcid.org/0000-0001-7022-8287</orcidid></search><sort><creationdate>20160503</creationdate><title>Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells</title><author>Viant, Charlotte ; Rankin, Lucille C ; Girard-Madoux, Mathilde J H ; Seillet, Cyril ; Shi, Wei ; Smyth, Mark J ; Bartholin, Laurent ; Walzer, Thierry ; Huntington, Nicholas D ; Vivier, Eric ; Belz, Gabrielle T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-cd3e4be980000a31c11b159f40bb1cf7f136c4ba31520e284d1f554ff85a02023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antigens, Ly - metabolism</topic><topic>Cell Differentiation</topic><topic>Cytokines - metabolism</topic><topic>Female</topic><topic>Immunity, Innate</topic><topic>Immunology</topic><topic>Intestines - metabolism</topic><topic>Life Sciences</topic><topic>Ligands</topic><topic>Lung - metabolism</topic><topic>Lymphocytes - cytology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Natural Cytotoxicity Triggering Receptor 1 - metabolism</topic><topic>Receptor, Notch1 - metabolism</topic><topic>Signal Transduction</topic><topic>T-Lymphocytes - cytology</topic><topic>Transcription, Genetic</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Viant, Charlotte</creatorcontrib><creatorcontrib>Rankin, Lucille C</creatorcontrib><creatorcontrib>Girard-Madoux, Mathilde J H</creatorcontrib><creatorcontrib>Seillet, Cyril</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><creatorcontrib>Smyth, Mark J</creatorcontrib><creatorcontrib>Bartholin, Laurent</creatorcontrib><creatorcontrib>Walzer, Thierry</creatorcontrib><creatorcontrib>Huntington, Nicholas D</creatorcontrib><creatorcontrib>Vivier, Eric</creatorcontrib><creatorcontrib>Belz, Gabrielle T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Science signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Viant, Charlotte</au><au>Rankin, Lucille C</au><au>Girard-Madoux, Mathilde J H</au><au>Seillet, Cyril</au><au>Shi, Wei</au><au>Smyth, Mark J</au><au>Bartholin, Laurent</au><au>Walzer, Thierry</au><au>Huntington, Nicholas D</au><au>Vivier, Eric</au><au>Belz, Gabrielle T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells</atitle><jtitle>Science signaling</jtitle><addtitle>Sci Signal</addtitle><date>2016-05-03</date><risdate>2016</risdate><volume>9</volume><issue>426</issue><spage>ra46</spage><epage>ra46</epage><pages>ra46-ra46</pages><issn>1945-0877</issn><issn>1937-9145</issn><eissn>1937-9145</eissn><abstract>Group 3 innate lymphoid cells (ILC3s) are composed of subsets that are either positive or negative for the natural cytotoxicity receptor (NCR) NKp46 (encoded by Ncr1). 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| ispartof | Science signaling, 2016-05, Vol.9 (426), p.ra46-ra46 |
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| source | MEDLINE; American Association for the Advancement of Science |
| subjects | Animals Antigens, Ly - metabolism Cell Differentiation Cytokines - metabolism Female Immunity, Innate Immunology Intestines - metabolism Life Sciences Ligands Lung - metabolism Lymphocytes - cytology Male Mice Mice, Transgenic Natural Cytotoxicity Triggering Receptor 1 - metabolism Receptor, Notch1 - metabolism Signal Transduction T-Lymphocytes - cytology Transcription, Genetic Transforming Growth Factor beta1 - metabolism |
| title | Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells |
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