Tissue-Specific Regulation of Drosophila NF-x03BA;B Pathway Activation by Peptidoglycan Recognition Protein SC

In Drosophila, peptidoglycan (PGN) is detected by PGN recognition proteins (PGRPs) that act as pattern recognition receptors. Some PGRPs such as PGRP-LB or PGRP-SCs are able to cleave PGN, therefore reducing the amount of immune elicitors and dampening immune deficiency (IMD) pathway activation. The...

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Veröffentlicht in:	Journal of innate immunity 2016, Vol.8 (1), p.67-80
Hauptverfasser:	Costechareyre, Denis, Capo, Florence, Fabre, Alexandre, Chaduli, Delphine, Kellenberger, Christine, Roussel, Alain, Charroux, Bernard, Royet, Julien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal biology Animals Animals Bacterial Load/immunology Carrier Proteins/genetics Carrier Proteins/immunology Carrier Proteins/metabolism Drosophila Proteins/genetics Drosophila Proteins/immunology Drosophila Proteins/metabolism Drosophila melanogaster/genetics Drosophila melanogaster/immunology Drosophila melanogaster/microbiology Fat Body/immunology Fat Body/metabolism Gene Expression Regulation Gene Knockout Techniques Gram-Positive Bacteria/immunology Immunity, Innate Intestines/immunology Intestines/metabolism NF-kappa B/metabolism Organ Specificity Peptidoglycan/metabolism Receptors, Pattern Recognition/genetics Receptors, Pattern Recognition/immunology Receptors, Pattern Recognition/metabolism Signal Transduction Bacterial Load - immunology Carrier Proteins - genetics Carrier Proteins - immunology Carrier Proteins - metabolism Cellular Biology Drosophila melanogaster - genetics Drosophila melanogaster - immunology Drosophila melanogaster - microbiology Drosophila Proteins - genetics Drosophila Proteins - immunology Drosophila Proteins - metabolism Fat Body - immunology Fat Body - metabolism Gene Expression Regulation Gene Knockout Techniques Gram-Positive Bacteria - immunology Immunity, Innate Intestines - immunology Intestines - metabolism Life Sciences NF-kappa B - metabolism Organ Specificity Peptidoglycan - metabolism Receptors, Pattern Recognition - genetics Receptors, Pattern Recognition - immunology Receptors, Pattern Recognition - metabolism Signal Transduction
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