Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor
Tissue engineering may constitute a promising alternative to current strategies in ligament repair, providing that suitable scaffolds and culture conditions are proposed. The objective of the present contribution is to present the design and instrumentation of a novel multi-chamber tension-torsion b...
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| Veröffentlicht in: | Processes 2014-03, Vol.2 (1), p.167-179 |
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| container_title | Processes |
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| creator | Laurent, Cedric P Vaquette, Cedryck Martin, Celine Guedon, Emmanuel Wu, Xiude Delconte, Alain Dumas, Dominique Hupont, Sebastien Isla, Natalia De Rahouadj, Rachid |
| description | Tissue engineering may constitute a promising alternative to current strategies in ligament repair, providing that suitable scaffolds and culture conditions are proposed. The objective of the present contribution is to present the design and instrumentation of a novel multi-chamber tension-torsion bioreactor dedicated to ligament tissue engineering. A preliminary biological evaluation of a new braided scaffold within this bioreactor under dynamic loading is reported, starting with the development of a dedicated seeding protocol validated from static cultures. The results of these preliminary biological characterizations confirm that the present combination of scaffold, seeding protocol and bioreactor may enable us to head towards a suitable ligament tissue-engineered construct. |
| doi_str_mv | 10.3390/pr2010167 |
| format | Article |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute |
| subjects | Biological Bioreactors Culture Engineering Sciences Ligaments Nucleation Scaffolds Strategy Tissue engineering |
| title | Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor |
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