3L-Phosphinothricin modulation of inwardly rectifying K+ channels increased excitability in striatal medium-sized spiny neurons

Phosphinotricin (L-PPT) is the active compound of a broad-spectrum herbicide. Acute poisoning with L-PPT has various clinical manifestations, including seizures and convulsions. However, the exact mechanism of L-PPT toxicity remains unclear. The present study addressed the role of L-PPT, in the exci...

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Veröffentlicht in:	Archives of toxicology 2016, Vol.90 (7), p.1719-1727
Hauptverfasser:	Domingos, Laetitia, Desrus, Agnès, Même, Sandra, Même, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences
Online-Zugang:	Volltext
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