Cross-resistance to elvitegravir and dolutegravir in 502 patients failing on raltegravir: a French national study of raltegravir-experienced HIV-1-infected patients

The objectives of this study were to determine the prevalence and patterns of resistance to integrase strand transfer inhibitors (INSTIs) in patients experiencing virological failure on raltegravir-based ART and the impact on susceptibility to INSTIs (raltegravir, elvitegravir and dolutegravir). Dat...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2015-05, Vol.70 (5), p.1507-1512
Hauptverfasser:	Fourati, Slim, Charpentier, Charlotte, Amiel, Corinne, Morand-Joubert, Laurence, Reigadas, Sandrine, Trabaud, Mary-Anne, Delaugerre, Constance, Nicot, Florence, Rodallec, Audrey, Maillard, Anne, Mirand, Audrey, Jeulin, Hélène, Montès, Brigitte, Barin, Francis, Bettinger, Dominique, Le Guillou-Guillemette, Hélène, Vallet, Sophie, Signori-Schmuck, Anne, Descamps, Diane, Calvez, Vincent, Flandre, Philippe, Marcelin, Anne-Genevieve
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antiretroviral drugs Drug resistance Drug Resistance, Viral Drug therapy Female France Heterocyclic Compounds, 3-Ring - pharmacology HIV HIV Infections - drug therapy HIV Infections - virology HIV Integrase - genetics HIV Protease - genetics HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus Humans Life Sciences Male Middle Aged Mutant Proteins - genetics Mutation Patients Quinolones - pharmacology Raltegravir Potassium - therapeutic use Sequence Analysis, DNA
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