A new stable GIP–Oxyntomodulin hybrid peptide improved bone strength both at the organ and tissue levels in genetically-inherited type 2 diabetes mellitus

Abstract Obesity and type 2 diabetes mellitus (T2DM) progress worldwide with detrimental effects on several physiological systems including bone tissue mainly by affecting bone quality. Several gut hormones analogues have been proven potent in ameliorating bone quality. In the present study, we used...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2016-06, Vol.87, p.102-113
Hauptverfasser:	Mansur, Sity Aishah, Mieczkowska, Aleksandra, Flatt, Peter R, Bouvard, Beatrice, Chappard, Daniel, Irwin, Nigel, Mabilleau, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	[d-Ala2]GIP–Oxm Absorptiometry, Photon Amino Acid Sequence Animals Body Composition - drug effects Bone and Bones - drug effects Bone and Bones - pathology Bone and Bones - physiopathology Bone Density - drug effects Bone quality Bone strength Cancellous Bone - drug effects Cancellous Bone - pathology Cancellous Bone - physiopathology Cortical Bone - drug effects Cortical Bone - pathology Cortical Bone - physiopathology db/db mice Densitometry Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Gastric Inhibitory Polypeptide - chemistry Gastric Inhibitory Polypeptide - pharmacology Gastric Inhibitory Polypeptide - therapeutic use Inheritance Patterns - genetics Life Sciences Male Mice Orthopedics Osteogenesis - drug effects Oxyntomodulin - chemistry Oxyntomodulin - pharmacology Oxyntomodulin - therapeutic use Type 2 diabetes mellitus
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