A study of a topiramate pre-treatment on the effects induced by a subanaesthetic dose of ketamine on human reaction time

Ketamine, a N-methyl- d-aspartate (NMDA) receptor antagonist, impairs reaction time performance and interacts with foreperiod duration, thereby suggesting that ketamine alters motor preparation. These effects can be attributed either to the blockade of NMDA receptors or to the stimulation of α-amino...

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Veröffentlicht in:	Neuroscience letters 2004-10, Vol.369 (2), p.99-103
Hauptverfasser:	Micallef, Joëlle, Gavaudan, Gilles, Burle, Boris, Blin, Olivier, Hasbroucq, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AMPA/kainate receptors Biological and medical sciences Choice Behavior - drug effects Choice Behavior - physiology Cognitive science Dose-Response Relationship, Drug Double-Blind Method Drug Interactions Excitatory Amino Acid Antagonists - pharmacology Fructose - analogs & derivatives Fructose - pharmacology Fundamental and applied biological sciences. Psychology Glutamate Humans Ketamine Ketamine - pharmacology Male Neuroprotective Agents - pharmacology Neuroscience NMDA receptor Reaction time Reaction Time - drug effects Topiramate Vertebrates: nervous system and sense organs
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