Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives

Novel regioisomers of trifluoromethylated cyclopropanes have been synthesized by Michael addition and nucleophilic cyclization process. The reaction was carried out with the trifluoromethylcrotonate 6 and nucleophilic reagents. Fluorinated cyclopropanes were obtained with good to excellent diastereo...

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Veröffentlicht in:	Tetrahedron 2013-04, Vol.69 (15), p.3308-3315
Hauptverfasser:	Keita, Massaba, De Bona, Rocco, Santos, Mickael Dos, Lequin, Olivier, Ongeri, Sandrine, Milcent, Thierry, Crousse, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Constrained amino acids Cyclopropanes Fluorine Life Sciences Michael addition Peptidomimetics
Online-Zugang:	Volltext
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