(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation

ABSTRACT The extracellular deposition of insoluble amyloid fibrils resulting from the aggregation of the amyloid‐β (Aβ) is a pathological feature of neuronal loss in Alzheimer's disease (AD). Numerous small molecules have been reported to interfere with the process of Aβ aggregation. Compounds...

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Veröffentlicht in:Biopolymers 2015-09, Vol.104 (5), p.601-610
Hauptverfasser: Botz, Alexandra, Gasparik, Vincent, Devillers, Emmanuelle, Hoffmann, Anais R. F., Caillon, Lucie, Chelain, Evelyne, Lequin, Olivier, Brigaud, Thierry, Khemtemourian, Lucie
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