Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry
[Display omitted] The development of bioactive phosphate-based glasses is essential in biomaterials science, and especially for bone substitution applications. In this context, the preparation of amorphous calcium-phosphorus hydroxide/oxide monoliths at low temperature is a key challenge for being a...
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| Veröffentlicht in: | Acta biomaterialia 2016-09, Vol.41, p.320-327 |
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| container_title | Acta biomaterialia |
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| creator | Soulié, Jérémy Gras, Pierre Marsan, Olivier Laurencin, Danielle Rey, Christian Combes, Christèle |
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The development of bioactive phosphate-based glasses is essential in biomaterials science, and especially for bone substitution applications. In this context, the preparation of amorphous calcium-phosphorus hydroxide/oxide monoliths at low temperature is a key challenge for being able to develop novel hybrid materials for these applications. We herein report for the first time the synthesis and physical chemical characterisation of a novel family of pyrophosphate-based glasses (with the formula: {[(Ca2+)1−x(H+/K+)2x]2[(P2O74−)1−y(PO43−)4y/3]} n(H2O)), which were prepared by soft chemistry using low temperatures (T |
| doi_str_mv | 10.1016/j.actbio.2016.05.030 |
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The development of bioactive phosphate-based glasses is essential in biomaterials science, and especially for bone substitution applications. In this context, the preparation of amorphous calcium-phosphorus hydroxide/oxide monoliths at low temperature is a key challenge for being able to develop novel hybrid materials for these applications. We herein report for the first time the synthesis and physical chemical characterisation of a novel family of pyrophosphate-based glasses (with the formula: {[(Ca2+)1−x(H+/K+)2x]2[(P2O74−)1−y(PO43−)4y/3]} n(H2O)), which were prepared by soft chemistry using low temperatures (T<70°C) and water as a solvent. The effect of the initial Ca/Pyrophosphate ratio on the structure and morphology of these pyrophosphate glasses was investigated in detail. Depending on this ratio, a glass (mixed calcium pyro- and orthophosphate) or a glass-ceramic (Ca10K4(P2O7)6·9H2O crystals embedded in the amorphous phase) was obtained. The proportion of the crystalline phase increased with an increase in the Ca/Pyrophosphate ratio in the batch solution. As expected for a glass, the formation of the glassy material was demonstrated not to be thermodynamically but rather kinetically driven, and the washing step was found to be crucial to prevent crystallisation. The stability of the amorphous phase was discussed considering the structural degrees of freedom of pyrophosphate entities, ionic strength of the initial solution and the inhibitory effect of orthophosphate ions. Overall, this new strategy of preparation of monolithic calcium-(pyro)phosphate based glasses using soft chemistry in water is highly promising in view of preparing new functional organic-inorganic hybrids for bone substitution applications.
Phosphate-based glasses have gradually emerged as a potential alternative to silicate bioactive glasses in order to induce different biological mechanisms of degradation. The synthesis of such monolithic glasses at low temperature is a key step to allow new inorganic glass compositions to be reached and hybrid materials to be prepared. Although sol-gel and coacervate methods (respectively orthophosphate and metaphosphate precursors) have already been described to prepare such glasses, the use of toxic solvents and/or the final temperature treatment associated to these processes could limit the use of these materials for biomedical applications and/or the further development of hybrids. It is shown here that pyrophosphate precursors are an alternative strategy to obtain monolithic calcium (pyro)phosphate glasses under soft conditions (water solvent, 70°C).</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2016.05.030</identifier><identifier>PMID: 27221792</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>(Pyro) phosphate glasses ; Biocompatibility ; Biomedical materials ; Bones ; Calcium ; Calcium Pyrophosphate - chemistry ; Chemical Sciences ; Chemistry, Inorganic - methods ; Differential Thermal Analysis ; Glass ; Glass - chemistry ; Hydrogen-Ion Concentration ; Material chemistry ; Microscopy, Electron, Scanning ; Monolith ; Precursors ; Soft chemistry ; Solutions ; Solvents ; Static Electricity ; Strategy ; Thermogravimetry</subject><ispartof>Acta biomaterialia, 2016-09, Vol.41, p.320-327</ispartof><rights>2016 Acta Materialia Inc.</rights><rights>Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-c16b86c984de4e4b8308781b82601f83d82bdd28febc4f671a0487e4e03a25ed3</citedby><cites>FETCH-LOGICAL-c508t-c16b86c984de4e4b8308781b82601f83d82bdd28febc4f671a0487e4e03a25ed3</cites><orcidid>0000-0002-8808-5947 ; 0000-0002-7445-0528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2016.05.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27221792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01361844$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Soulié, Jérémy</creatorcontrib><creatorcontrib>Gras, Pierre</creatorcontrib><creatorcontrib>Marsan, Olivier</creatorcontrib><creatorcontrib>Laurencin, Danielle</creatorcontrib><creatorcontrib>Rey, Christian</creatorcontrib><creatorcontrib>Combes, Christèle</creatorcontrib><title>Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
The development of bioactive phosphate-based glasses is essential in biomaterials science, and especially for bone substitution applications. In this context, the preparation of amorphous calcium-phosphorus hydroxide/oxide monoliths at low temperature is a key challenge for being able to develop novel hybrid materials for these applications. We herein report for the first time the synthesis and physical chemical characterisation of a novel family of pyrophosphate-based glasses (with the formula: {[(Ca2+)1−x(H+/K+)2x]2[(P2O74−)1−y(PO43−)4y/3]} n(H2O)), which were prepared by soft chemistry using low temperatures (T<70°C) and water as a solvent. The effect of the initial Ca/Pyrophosphate ratio on the structure and morphology of these pyrophosphate glasses was investigated in detail. Depending on this ratio, a glass (mixed calcium pyro- and orthophosphate) or a glass-ceramic (Ca10K4(P2O7)6·9H2O crystals embedded in the amorphous phase) was obtained. The proportion of the crystalline phase increased with an increase in the Ca/Pyrophosphate ratio in the batch solution. As expected for a glass, the formation of the glassy material was demonstrated not to be thermodynamically but rather kinetically driven, and the washing step was found to be crucial to prevent crystallisation. The stability of the amorphous phase was discussed considering the structural degrees of freedom of pyrophosphate entities, ionic strength of the initial solution and the inhibitory effect of orthophosphate ions. Overall, this new strategy of preparation of monolithic calcium-(pyro)phosphate based glasses using soft chemistry in water is highly promising in view of preparing new functional organic-inorganic hybrids for bone substitution applications.
Phosphate-based glasses have gradually emerged as a potential alternative to silicate bioactive glasses in order to induce different biological mechanisms of degradation. The synthesis of such monolithic glasses at low temperature is a key step to allow new inorganic glass compositions to be reached and hybrid materials to be prepared. Although sol-gel and coacervate methods (respectively orthophosphate and metaphosphate precursors) have already been described to prepare such glasses, the use of toxic solvents and/or the final temperature treatment associated to these processes could limit the use of these materials for biomedical applications and/or the further development of hybrids. It is shown here that pyrophosphate precursors are an alternative strategy to obtain monolithic calcium (pyro)phosphate glasses under soft conditions (water solvent, 70°C).</description><subject>(Pyro) phosphate glasses</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Calcium</subject><subject>Calcium Pyrophosphate - chemistry</subject><subject>Chemical Sciences</subject><subject>Chemistry, Inorganic - methods</subject><subject>Differential Thermal Analysis</subject><subject>Glass</subject><subject>Glass - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Material chemistry</subject><subject>Microscopy, Electron, Scanning</subject><subject>Monolith</subject><subject>Precursors</subject><subject>Soft chemistry</subject><subject>Solutions</subject><subject>Solvents</subject><subject>Static Electricity</subject><subject>Strategy</subject><subject>Thermogravimetry</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQQC0EoqXwDxDysT0k-CuOe0GqCrRIK3GBEwfLcSbEKycOtner_Hu8Sumx4mTP6I1nPA-h95TUlFD5cV8bmzsXalaimjQ14eQFOqeqVVXbSPWy3FvBqpZIeobepLQnhCvK1Gt0xlrGaHvNztGvz3AEH5YJ5ozDgA2e4QEPZnJ-PcVTmIN3eXQWW-OtO0z4clljuFrGkJbRZMC_vUkJEu5WnMKQsR1hcinH9S16NRif4N3jeYF-fv3y4_a-2n2_-3Z7s6tsQ1SuLJWdkvZaiR4EiE5xUv5AO8UkoYPivWJd3zM1QGfFIFtqiFBtQQk3rIGeX6Cr7d3ReL1EN5m46mCcvr_Z6VOOUC6pEuJIC3u5sUsMfw6Qsi6zWvDezBAOSVPFG8lJw5v_QGlZtqREFVRsqI0hpQjD0xiU6JMtvdebLX2ypUmji61S9uGxw6GboH8q-qenAJ82AMr6jg6iTtbBbKF3EWzWfXDPd_gLLemmtQ</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Soulié, Jérémy</creator><creator>Gras, Pierre</creator><creator>Marsan, Olivier</creator><creator>Laurencin, Danielle</creator><creator>Rey, Christian</creator><creator>Combes, Christèle</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-8808-5947</orcidid><orcidid>https://orcid.org/0000-0002-7445-0528</orcidid></search><sort><creationdate>20160901</creationdate><title>Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry</title><author>Soulié, Jérémy ; Gras, Pierre ; Marsan, Olivier ; Laurencin, Danielle ; Rey, Christian ; Combes, Christèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-c16b86c984de4e4b8308781b82601f83d82bdd28febc4f671a0487e4e03a25ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>(Pyro) phosphate glasses</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bones</topic><topic>Calcium</topic><topic>Calcium Pyrophosphate - chemistry</topic><topic>Chemical Sciences</topic><topic>Chemistry, Inorganic - methods</topic><topic>Differential Thermal Analysis</topic><topic>Glass</topic><topic>Glass - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Material chemistry</topic><topic>Microscopy, Electron, Scanning</topic><topic>Monolith</topic><topic>Precursors</topic><topic>Soft chemistry</topic><topic>Solutions</topic><topic>Solvents</topic><topic>Static Electricity</topic><topic>Strategy</topic><topic>Thermogravimetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soulié, Jérémy</creatorcontrib><creatorcontrib>Gras, Pierre</creatorcontrib><creatorcontrib>Marsan, Olivier</creatorcontrib><creatorcontrib>Laurencin, Danielle</creatorcontrib><creatorcontrib>Rey, Christian</creatorcontrib><creatorcontrib>Combes, Christèle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soulié, Jérémy</au><au>Gras, Pierre</au><au>Marsan, Olivier</au><au>Laurencin, Danielle</au><au>Rey, Christian</au><au>Combes, Christèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>41</volume><spage>320</spage><epage>327</epage><pages>320-327</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
The development of bioactive phosphate-based glasses is essential in biomaterials science, and especially for bone substitution applications. In this context, the preparation of amorphous calcium-phosphorus hydroxide/oxide monoliths at low temperature is a key challenge for being able to develop novel hybrid materials for these applications. We herein report for the first time the synthesis and physical chemical characterisation of a novel family of pyrophosphate-based glasses (with the formula: {[(Ca2+)1−x(H+/K+)2x]2[(P2O74−)1−y(PO43−)4y/3]} n(H2O)), which were prepared by soft chemistry using low temperatures (T<70°C) and water as a solvent. The effect of the initial Ca/Pyrophosphate ratio on the structure and morphology of these pyrophosphate glasses was investigated in detail. Depending on this ratio, a glass (mixed calcium pyro- and orthophosphate) or a glass-ceramic (Ca10K4(P2O7)6·9H2O crystals embedded in the amorphous phase) was obtained. The proportion of the crystalline phase increased with an increase in the Ca/Pyrophosphate ratio in the batch solution. As expected for a glass, the formation of the glassy material was demonstrated not to be thermodynamically but rather kinetically driven, and the washing step was found to be crucial to prevent crystallisation. The stability of the amorphous phase was discussed considering the structural degrees of freedom of pyrophosphate entities, ionic strength of the initial solution and the inhibitory effect of orthophosphate ions. Overall, this new strategy of preparation of monolithic calcium-(pyro)phosphate based glasses using soft chemistry in water is highly promising in view of preparing new functional organic-inorganic hybrids for bone substitution applications.
Phosphate-based glasses have gradually emerged as a potential alternative to silicate bioactive glasses in order to induce different biological mechanisms of degradation. The synthesis of such monolithic glasses at low temperature is a key step to allow new inorganic glass compositions to be reached and hybrid materials to be prepared. Although sol-gel and coacervate methods (respectively orthophosphate and metaphosphate precursors) have already been described to prepare such glasses, the use of toxic solvents and/or the final temperature treatment associated to these processes could limit the use of these materials for biomedical applications and/or the further development of hybrids. It is shown here that pyrophosphate precursors are an alternative strategy to obtain monolithic calcium (pyro)phosphate glasses under soft conditions (water solvent, 70°C).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27221792</pmid><doi>10.1016/j.actbio.2016.05.030</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8808-5947</orcidid><orcidid>https://orcid.org/0000-0002-7445-0528</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta biomaterialia, 2016-09, Vol.41, p.320-327 |
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| subjects | (Pyro) phosphate glasses Biocompatibility Biomedical materials Bones Calcium Calcium Pyrophosphate - chemistry Chemical Sciences Chemistry, Inorganic - methods Differential Thermal Analysis Glass Glass - chemistry Hydrogen-Ion Concentration Material chemistry Microscopy, Electron, Scanning Monolith Precursors Soft chemistry Solutions Solvents Static Electricity Strategy Thermogravimetry |
| title | Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry |
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