Impact of anxiety on verbal and visuospatial working memory in patients with acute stroke without severe cognitive impairment
Background Working memory is the most impaired cognitive domain in the acute phase of stroke. In a context where anxiety is highly prevalent, close attention must be paid to anxiety which could mimic mild to moderate working memory impairments. This is the first study to assess the contribution of s...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2015-05, Vol.86 (5), p.513-519 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Grosdemange, Antoine Monfort, Vincent Richard, Sébastien Toniolo, Anne-Marie Ducrocq, Xavier Bolmont, Benoît |
| description | Background Working memory is the most impaired cognitive domain in the acute phase of stroke. In a context where anxiety is highly prevalent, close attention must be paid to anxiety which could mimic mild to moderate working memory impairments. This is the first study to assess the contribution of state anxiety (the currently experienced level of anxiety) to the working memory (verbal, visuospatial) in patients with first-ever acute stroke without severe cognitive impairment. Methods 28 patients with first-ever acute stroke and 41 matched control subjects were exposed to a neutral condition and an anxiogenic condition in which verbal (VWM) and visuospatial working memory (VSWM) performance and state anxiety were assessed. State anxiety was assessed before the beginning of the experiment (baseline), after the neutral condition and after the anxiogenic condition. Results The mean state anxiety score was higher in patients than in controls in the neutral (z=1.9, p |
| doi_str_mv | 10.1136/jnnp-2014-308232 |
| format | Article |
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In a context where anxiety is highly prevalent, close attention must be paid to anxiety which could mimic mild to moderate working memory impairments. This is the first study to assess the contribution of state anxiety (the currently experienced level of anxiety) to the working memory (verbal, visuospatial) in patients with first-ever acute stroke without severe cognitive impairment. Methods 28 patients with first-ever acute stroke and 41 matched control subjects were exposed to a neutral condition and an anxiogenic condition in which verbal (VWM) and visuospatial working memory (VSWM) performance and state anxiety were assessed. State anxiety was assessed before the beginning of the experiment (baseline), after the neutral condition and after the anxiogenic condition. Results The mean state anxiety score was higher in patients than in controls in the neutral (z=1.9, p<0.05) and anxiogenic (z=2, p<0.05) conditions despite a similar level at baseline. Multiple regression analyses with a dummy variable ‘group’ (patients vs controls) showed that increased state anxiety in patients contributed significantly more to both reduced VWM (β=−0.93, p<0.05) and VSWM (β=−1, p<0.05) performance between the neutral and anxiogenic conditions compared to controls. Conclusions In a stressful context, the contribution of state anxiety to reduced working memory performance is more pronounced in patients with acute stroke than in controls. These results are of particular relevance for clinicians assessing patients in the acute phase of stroke in which anxiety is highly prevalent.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp-2014-308232</identifier><identifier>PMID: 25224674</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Aged ; Anxiety ; Anxiety - complications ; Anxiety - psychology ; Case-Control Studies ; Computer Science ; Female ; Functional Laterality ; Humans ; Male ; Memory, Short-Term ; Neuropsychological Tests ; Prospective Studies ; Stroke - complications ; Stroke - psychology</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2015-05, Vol.86 (5), p.513-519</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b430t-7d39751d1de7456e404e633f9b1ec9b3472707d695988148a3712f3481914d403</citedby><cites>FETCH-LOGICAL-b430t-7d39751d1de7456e404e633f9b1ec9b3472707d695988148a3712f3481914d403</cites><orcidid>0000-0002-0945-5656 ; 0000-0003-4828-9715 ; 0000-0002-2442-3169</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/86/5/513.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/86/5/513.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,780,784,885,3187,23562,27915,27916,77361,77392</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25224674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01344860$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Grosdemange, Antoine</creatorcontrib><creatorcontrib>Monfort, Vincent</creatorcontrib><creatorcontrib>Richard, Sébastien</creatorcontrib><creatorcontrib>Toniolo, Anne-Marie</creatorcontrib><creatorcontrib>Ducrocq, Xavier</creatorcontrib><creatorcontrib>Bolmont, Benoît</creatorcontrib><title>Impact of anxiety on verbal and visuospatial working memory in patients with acute stroke without severe cognitive impairment</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Background Working memory is the most impaired cognitive domain in the acute phase of stroke. In a context where anxiety is highly prevalent, close attention must be paid to anxiety which could mimic mild to moderate working memory impairments. This is the first study to assess the contribution of state anxiety (the currently experienced level of anxiety) to the working memory (verbal, visuospatial) in patients with first-ever acute stroke without severe cognitive impairment. Methods 28 patients with first-ever acute stroke and 41 matched control subjects were exposed to a neutral condition and an anxiogenic condition in which verbal (VWM) and visuospatial working memory (VSWM) performance and state anxiety were assessed. State anxiety was assessed before the beginning of the experiment (baseline), after the neutral condition and after the anxiogenic condition. Results The mean state anxiety score was higher in patients than in controls in the neutral (z=1.9, p<0.05) and anxiogenic (z=2, p<0.05) conditions despite a similar level at baseline. Multiple regression analyses with a dummy variable ‘group’ (patients vs controls) showed that increased state anxiety in patients contributed significantly more to both reduced VWM (β=−0.93, p<0.05) and VSWM (β=−1, p<0.05) performance between the neutral and anxiogenic conditions compared to controls. Conclusions In a stressful context, the contribution of state anxiety to reduced working memory performance is more pronounced in patients with acute stroke than in controls. These results are of particular relevance for clinicians assessing patients in the acute phase of stroke in which anxiety is highly prevalent.</description><subject>Aged</subject><subject>Anxiety</subject><subject>Anxiety - complications</subject><subject>Anxiety - psychology</subject><subject>Case-Control Studies</subject><subject>Computer Science</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Male</subject><subject>Memory, Short-Term</subject><subject>Neuropsychological Tests</subject><subject>Prospective Studies</subject><subject>Stroke - complications</subject><subject>Stroke - psychology</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkb1v1TAUxS1ERR-FnQlZYilCAX8ldsaqAlrpSV1AYrOc5Kb1a2IH23nlDfzvOKTt0KVeLJ37O8fXOgi9o-Qzpbz6snNuKhihouBEMc5eoA0VlSo4J79eog0hjOVJSY7R6xh3ZDmqfoWOWcmYqKTYoL-X42TahH2PjftjIR2wd3gPoTFDVjq8t3H2cTLJZuHOh1vrrvEIow8HbB1eBuBSxHc23WDTzglwTMHfwn_FzwlHyHGAW3_tbLJ7wDY_acOYbW_QUW-GCG_v7xP089vXH-cXxfbq--X52bZoBCepkB2vZUk72oEUZQWCCKg47-uGQls3XEgmieyquqyVokIZLinruVC0pqIThJ-gj2vujRn0FOxowkF7Y_XF2VYvGqFcCFWRPc3s6cpOwf-eISY92tjCMBgHfo6aKqJyvKTkebSSnEvGWJ3RD0_QnZ-Dy5_WVCrKyrw2yxRZqTb4GAP0j8tSopfG9dK4XhrXa-PZ8v4-eG5G6B4NDxVn4NMKNOPu-bh_x0Gztg</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Grosdemange, Antoine</creator><creator>Monfort, Vincent</creator><creator>Richard, Sébastien</creator><creator>Toniolo, Anne-Marie</creator><creator>Ducrocq, Xavier</creator><creator>Bolmont, Benoît</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0945-5656</orcidid><orcidid>https://orcid.org/0000-0003-4828-9715</orcidid><orcidid>https://orcid.org/0000-0002-2442-3169</orcidid></search><sort><creationdate>20150501</creationdate><title>Impact of anxiety on verbal and visuospatial working memory in patients with acute stroke without severe cognitive impairment</title><author>Grosdemange, Antoine ; Monfort, Vincent ; Richard, Sébastien ; Toniolo, Anne-Marie ; Ducrocq, Xavier ; Bolmont, Benoît</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b430t-7d39751d1de7456e404e633f9b1ec9b3472707d695988148a3712f3481914d403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Anxiety</topic><topic>Anxiety - complications</topic><topic>Anxiety - psychology</topic><topic>Case-Control Studies</topic><topic>Computer Science</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Male</topic><topic>Memory, Short-Term</topic><topic>Neuropsychological Tests</topic><topic>Prospective Studies</topic><topic>Stroke - complications</topic><topic>Stroke - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grosdemange, Antoine</creatorcontrib><creatorcontrib>Monfort, Vincent</creatorcontrib><creatorcontrib>Richard, Sébastien</creatorcontrib><creatorcontrib>Toniolo, Anne-Marie</creatorcontrib><creatorcontrib>Ducrocq, Xavier</creatorcontrib><creatorcontrib>Bolmont, Benoît</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>ProQuest Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grosdemange, Antoine</au><au>Monfort, Vincent</au><au>Richard, Sébastien</au><au>Toniolo, Anne-Marie</au><au>Ducrocq, Xavier</au><au>Bolmont, Benoît</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of anxiety on verbal and visuospatial working memory in patients with acute stroke without severe cognitive impairment</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>86</volume><issue>5</issue><spage>513</spage><epage>519</epage><pages>513-519</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Background Working memory is the most impaired cognitive domain in the acute phase of stroke. In a context where anxiety is highly prevalent, close attention must be paid to anxiety which could mimic mild to moderate working memory impairments. This is the first study to assess the contribution of state anxiety (the currently experienced level of anxiety) to the working memory (verbal, visuospatial) in patients with first-ever acute stroke without severe cognitive impairment. Methods 28 patients with first-ever acute stroke and 41 matched control subjects were exposed to a neutral condition and an anxiogenic condition in which verbal (VWM) and visuospatial working memory (VSWM) performance and state anxiety were assessed. State anxiety was assessed before the beginning of the experiment (baseline), after the neutral condition and after the anxiogenic condition. Results The mean state anxiety score was higher in patients than in controls in the neutral (z=1.9, p<0.05) and anxiogenic (z=2, p<0.05) conditions despite a similar level at baseline. Multiple regression analyses with a dummy variable ‘group’ (patients vs controls) showed that increased state anxiety in patients contributed significantly more to both reduced VWM (β=−0.93, p<0.05) and VSWM (β=−1, p<0.05) performance between the neutral and anxiogenic conditions compared to controls. Conclusions In a stressful context, the contribution of state anxiety to reduced working memory performance is more pronounced in patients with acute stroke than in controls. These results are of particular relevance for clinicians assessing patients in the acute phase of stroke in which anxiety is highly prevalent.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>25224674</pmid><doi>10.1136/jnnp-2014-308232</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0945-5656</orcidid><orcidid>https://orcid.org/0000-0003-4828-9715</orcidid><orcidid>https://orcid.org/0000-0002-2442-3169</orcidid></addata></record> |
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| subjects | Aged Anxiety Anxiety - complications Anxiety - psychology Case-Control Studies Computer Science Female Functional Laterality Humans Male Memory, Short-Term Neuropsychological Tests Prospective Studies Stroke - complications Stroke - psychology |
| title | Impact of anxiety on verbal and visuospatial working memory in patients with acute stroke without severe cognitive impairment |
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