T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury
Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II–induced hypertension and vascular injury. Ten- t...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2011-03, Vol.57 (3), p.469-476 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 476 |
|---|---|
| container_issue | 3 |
| container_start_page | 469 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 57 |
| creator | Barhoumi, Tlili Kasal, Daniel A Li, Melissa W Shbat, Layla Laurant, Pascal Neves, Mario F Paradis, Pierre Schiffrin, Ernesto L |
| description | Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II–induced hypertension and vascular injury. Ten- to 12-week–old male C57BL/6 mice were injected IV with 3×10 Treg (CD4CD25) or T effector (CD4CD25) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.110.162941 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01333877v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>852902060</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5361-73b66971465ee5e41beef938482ddddec06f79694e9f7b0060c0e095f52e22983</originalsourceid><addsrcrecordid>eNpdkVFv0zAQxy0EYt3gK6AICSEeAj7bcWLeoqkskaptGgUBL5abXNaM1Cl2silvfAe-IZ8Edy1D4iTLurvf_c--I-Ql0LcAEt4VXy_nV8v5-cfy4jwv8hAMCcmUgEdkBgkTsUgkf0xmFJSIFcCXI3Ls_Q2lIIRIn5IjBkxyYMmMfFtGV3g9dmbo3RQtps123VfTgD66dHiLdohye932A1rf2qgsf__8Vdp6rLCOimmL7j7R28jYOvpsfBWUXFTam9FNz8iTxnQenx_uE_Lpw3x5WsSLi7PyNF_EVcIlxClfSalSEDJBTFDACrFRPBMZq4NhRWWTKqkEqiZdUSppRZGqpEkYMqYyfkLe7HXXptNb126Mm3RvWl3kC72LUeCcZ2l6C4F9vWe3rv8xoh_0pvUVdp2x2I9eZwlTlIUegXy_JyvXe--weZAGqndr0P-tIQRD4n4NofjFoc242mD9UPp37gF4dQDCzEzXOGOr1v_jeCbDG3Z_E3vuru8GdP57N96h02s03bDWNJhgMosZDc158OJwGPA_ZiyiMw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>852902060</pqid></control><display><type>article</type><title>T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Barhoumi, Tlili ; Kasal, Daniel A ; Li, Melissa W ; Shbat, Layla ; Laurant, Pascal ; Neves, Mario F ; Paradis, Pierre ; Schiffrin, Ernesto L</creator><creatorcontrib>Barhoumi, Tlili ; Kasal, Daniel A ; Li, Melissa W ; Shbat, Layla ; Laurant, Pascal ; Neves, Mario F ; Paradis, Pierre ; Schiffrin, Ernesto L</creatorcontrib><description><![CDATA[Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II–induced hypertension and vascular injury. Ten- to 12-week–old male C57BL/6 mice were injected IV with 3×10 Treg (CD4CD25) or T effector (CD4CD25) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P<0.05), NADPH oxidase activity 1.5-fold in aorta and 1.8-fold in the heart (P<0.05), impaired acetylcholine vasodilatory responses by 70% compared with control (P<0.05), and increased vascular stiffness (P<0.001), mesenteric artery vascular cell adhesion molecule expression (2-fold; P<0.05), and aortic macrophage and T-cell infiltration (P<0.001). All of the above were prevented by Treg but not T effector adoptive transfer. Ang II caused a 43% decrease in Foxp3 cells in the renal cortex, whereas Treg adoptive transfer increased Foxp3 cells 2-fold compared with control. Thus, Tregs suppress Ang II–mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II–induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction.]]></description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.110.162941</identifier><identifier>PMID: 21263125</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Acetylcholine - pharmacology ; Adaptive Immunity - immunology ; Analysis of Variance ; Angiotensin II - pharmacology ; Animals ; Aorta - immunology ; Aorta - metabolism ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood Pressure - immunology ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Endothelium, Vascular - immunology ; Endothelium, Vascular - metabolism ; Flow Cytometry ; Hypertension - chemically induced ; Hypertension - immunology ; Hypertension - metabolism ; Life Sciences ; Male ; Medical sciences ; Mesenteric Arteries - immunology ; Mesenteric Arteries - metabolism ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism ; Vascular Cell Adhesion Molecule-1 - immunology ; Vascular Cell Adhesion Molecule-1 - metabolism ; Vasodilator Agents - pharmacology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2011-03, Vol.57 (3), p.469-476</ispartof><rights>2011 American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5361-73b66971465ee5e41beef938482ddddec06f79694e9f7b0060c0e095f52e22983</citedby><cites>FETCH-LOGICAL-c5361-73b66971465ee5e41beef938482ddddec06f79694e9f7b0060c0e095f52e22983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,3674,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23866038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21263125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01333877$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Barhoumi, Tlili</creatorcontrib><creatorcontrib>Kasal, Daniel A</creatorcontrib><creatorcontrib>Li, Melissa W</creatorcontrib><creatorcontrib>Shbat, Layla</creatorcontrib><creatorcontrib>Laurant, Pascal</creatorcontrib><creatorcontrib>Neves, Mario F</creatorcontrib><creatorcontrib>Paradis, Pierre</creatorcontrib><creatorcontrib>Schiffrin, Ernesto L</creatorcontrib><title>T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description><![CDATA[Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II–induced hypertension and vascular injury. Ten- to 12-week–old male C57BL/6 mice were injected IV with 3×10 Treg (CD4CD25) or T effector (CD4CD25) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P<0.05), NADPH oxidase activity 1.5-fold in aorta and 1.8-fold in the heart (P<0.05), impaired acetylcholine vasodilatory responses by 70% compared with control (P<0.05), and increased vascular stiffness (P<0.001), mesenteric artery vascular cell adhesion molecule expression (2-fold; P<0.05), and aortic macrophage and T-cell infiltration (P<0.001). All of the above were prevented by Treg but not T effector adoptive transfer. Ang II caused a 43% decrease in Foxp3 cells in the renal cortex, whereas Treg adoptive transfer increased Foxp3 cells 2-fold compared with control. Thus, Tregs suppress Ang II–mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II–induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction.]]></description><subject>Acetylcholine - pharmacology</subject><subject>Adaptive Immunity - immunology</subject><subject>Analysis of Variance</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Aorta - immunology</subject><subject>Aorta - metabolism</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - immunology</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Endothelium, Vascular - immunology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Flow Cytometry</subject><subject>Hypertension - chemically induced</subject><subject>Hypertension - immunology</subject><subject>Hypertension - metabolism</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenteric Arteries - immunology</subject><subject>Mesenteric Arteries - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>Vascular Cell Adhesion Molecule-1 - immunology</subject><subject>Vascular Cell Adhesion Molecule-1 - metabolism</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVFv0zAQxy0EYt3gK6AICSEeAj7bcWLeoqkskaptGgUBL5abXNaM1Cl2silvfAe-IZ8Edy1D4iTLurvf_c--I-Ql0LcAEt4VXy_nV8v5-cfy4jwv8hAMCcmUgEdkBgkTsUgkf0xmFJSIFcCXI3Ls_Q2lIIRIn5IjBkxyYMmMfFtGV3g9dmbo3RQtps123VfTgD66dHiLdohye932A1rf2qgsf__8Vdp6rLCOimmL7j7R28jYOvpsfBWUXFTam9FNz8iTxnQenx_uE_Lpw3x5WsSLi7PyNF_EVcIlxClfSalSEDJBTFDACrFRPBMZq4NhRWWTKqkEqiZdUSppRZGqpEkYMqYyfkLe7HXXptNb126Mm3RvWl3kC72LUeCcZ2l6C4F9vWe3rv8xoh_0pvUVdp2x2I9eZwlTlIUegXy_JyvXe--weZAGqndr0P-tIQRD4n4NofjFoc242mD9UPp37gF4dQDCzEzXOGOr1v_jeCbDG3Z_E3vuru8GdP57N96h02s03bDWNJhgMosZDc158OJwGPA_ZiyiMw</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Barhoumi, Tlili</creator><creator>Kasal, Daniel A</creator><creator>Li, Melissa W</creator><creator>Shbat, Layla</creator><creator>Laurant, Pascal</creator><creator>Neves, Mario F</creator><creator>Paradis, Pierre</creator><creator>Schiffrin, Ernesto L</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><general>American Heart Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>201103</creationdate><title>T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury</title><author>Barhoumi, Tlili ; Kasal, Daniel A ; Li, Melissa W ; Shbat, Layla ; Laurant, Pascal ; Neves, Mario F ; Paradis, Pierre ; Schiffrin, Ernesto L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5361-73b66971465ee5e41beef938482ddddec06f79694e9f7b0060c0e095f52e22983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Adaptive Immunity - immunology</topic><topic>Analysis of Variance</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Aorta - immunology</topic><topic>Aorta - metabolism</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - immunology</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Endothelium, Vascular - immunology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Flow Cytometry</topic><topic>Hypertension - chemically induced</topic><topic>Hypertension - immunology</topic><topic>Hypertension - metabolism</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenteric Arteries - immunology</topic><topic>Mesenteric Arteries - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><topic>Vascular Cell Adhesion Molecule-1 - immunology</topic><topic>Vascular Cell Adhesion Molecule-1 - metabolism</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barhoumi, Tlili</creatorcontrib><creatorcontrib>Kasal, Daniel A</creatorcontrib><creatorcontrib>Li, Melissa W</creatorcontrib><creatorcontrib>Shbat, Layla</creatorcontrib><creatorcontrib>Laurant, Pascal</creatorcontrib><creatorcontrib>Neves, Mario F</creatorcontrib><creatorcontrib>Paradis, Pierre</creatorcontrib><creatorcontrib>Schiffrin, Ernesto L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barhoumi, Tlili</au><au>Kasal, Daniel A</au><au>Li, Melissa W</au><au>Shbat, Layla</au><au>Laurant, Pascal</au><au>Neves, Mario F</au><au>Paradis, Pierre</au><au>Schiffrin, Ernesto L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2011-03</date><risdate>2011</risdate><volume>57</volume><issue>3</issue><spage>469</spage><epage>476</epage><pages>469-476</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract><![CDATA[Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II–induced hypertension and vascular injury. Ten- to 12-week–old male C57BL/6 mice were injected IV with 3×10 Treg (CD4CD25) or T effector (CD4CD25) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P<0.05), NADPH oxidase activity 1.5-fold in aorta and 1.8-fold in the heart (P<0.05), impaired acetylcholine vasodilatory responses by 70% compared with control (P<0.05), and increased vascular stiffness (P<0.001), mesenteric artery vascular cell adhesion molecule expression (2-fold; P<0.05), and aortic macrophage and T-cell infiltration (P<0.001). All of the above were prevented by Treg but not T effector adoptive transfer. Ang II caused a 43% decrease in Foxp3 cells in the renal cortex, whereas Treg adoptive transfer increased Foxp3 cells 2-fold compared with control. Thus, Tregs suppress Ang II–mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II–induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction.]]></abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>21263125</pmid><doi>10.1161/HYPERTENSIONAHA.110.162941</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2011-03, Vol.57 (3), p.469-476 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01333877v1 |
| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Acetylcholine - pharmacology Adaptive Immunity - immunology Analysis of Variance Angiotensin II - pharmacology Animals Aorta - immunology Aorta - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - immunology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Flow Cytometry Hypertension - chemically induced Hypertension - immunology Hypertension - metabolism Life Sciences Male Medical sciences Mesenteric Arteries - immunology Mesenteric Arteries - metabolism Mice Mice, Inbred C57BL T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Vascular Cell Adhesion Molecule-1 - immunology Vascular Cell Adhesion Molecule-1 - metabolism Vasodilator Agents - pharmacology |
| title | T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T02%3A03%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=T%20Regulatory%20Lymphocytes%20Prevent%20Angiotensin%20II%E2%80%93Induced%20Hypertension%20and%20Vascular%20Injury&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Barhoumi,%20Tlili&rft.date=2011-03&rft.volume=57&rft.issue=3&rft.spage=469&rft.epage=476&rft.pages=469-476&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/HYPERTENSIONAHA.110.162941&rft_dat=%3Cproquest_hal_p%3E852902060%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=852902060&rft_id=info:pmid/21263125&rfr_iscdi=true |