Sarcomatoid lung carcinomas show high levels of Programmed Death Ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages
Highlights • PD-L1, tumor-infiltrating lymphocytes (TIL) were higher in SC than in NSCLC. • High levels of TIL constituted a factor of good prognosis. • PD-L1 expression distinguishes subpopulations within tumor-infiltrating lymphocytes (CD3+ or CD4+) with different prognosis. • This result could re...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-08, Vol.98, p.51-58 |
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| container_title | Lung cancer (Amsterdam, Netherlands) |
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| creator | Vieira, Thibault Antoine, Martine Hamard, Cécile Fallet, Vincent Duruisseaux, Michael Rabbe, Nathalie Rodenas, Anita Cadranel, Jacques Wislez, Marie |
| description | Highlights • PD-L1, tumor-infiltrating lymphocytes (TIL) were higher in SC than in NSCLC. • High levels of TIL constituted a factor of good prognosis. • PD-L1 expression distinguishes subpopulations within tumor-infiltrating lymphocytes (CD3+ or CD4+) with different prognosis. • This result could represent a justification for the use of PD-L1/PD-1 immunotherapy. |
| doi_str_mv | 10.1016/j.lungcan.2016.05.013 |
| format | Article |
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| ispartof | Lung cancer (Amsterdam, Netherlands), 2016-08, Vol.98, p.51-58 |
| issn | 0169-5002 1872-8332 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biomarkers, Tumor Cancer Female Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Life Sciences Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lung sarcomatoid carcinoma Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Middle Aged Mutation Neoplasm Metastasis Neoplasm Staging Non-small-cell lung cancer Odds Ratio PD-L1 Prognosis Pulmonary/Respiratory Tumor-Infiltrating lymphocytes Tumor-Infiltratingmacrophages |
| title | Sarcomatoid lung carcinomas show high levels of Programmed Death Ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages |
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