Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents
Context and Objective: This study aimed to comprehensively assess the macro- and microcirculation of severely obese adolescents (SOA) and normal-weight counterparts and to determine the longitudinal effects of weight loss on vascular function in SOA. Design, Setting, Participants, and Outcome Measur...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2014-03, Vol.99 (3), p.1019-1026 |
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| creator | Montero, David Walther, Guillaume Perez-Martin, Antonia Mercier, Charles S Gayrard, Sandrine Vicente-Salar, Nestor Sempere-Ortells, José Miguel Martinez-Peinado, Pascual Roche, Enrique Vinet, Agnès |
| description | Context and Objective:
This study aimed to comprehensively assess the macro- and microcirculation of severely obese adolescents (SOA) and normal-weight counterparts and to determine the longitudinal effects of weight loss on vascular function in SOA.
Design, Setting, Participants, and Outcome Measures:
Seventeen SOA (body mass index z-score = 4.22 ± 0.73) and 19 puberty-matched normal-weight counterparts (body mass index z-score = −0.02 ± 1.04) were included. The SOA participated in a 4 month weight loss program. Brachial artery flow-mediated dilation and response to sublingual nitrate (nitrate-mediated dilation [NMD]) were assessed by high-resolution ultrasound. Microvascular reactivity was evaluated by laser Doppler flowmetry in response to NMD, iontophoresis of acetylcholine and sodium nitroprusside, and local hyperthermia. Plasma insulin, leptin, resistin, C-reactive protein, myeloperoxidase, and tissue plasminogen activator were measured.
Results:
At baseline, SOA had similar flow-mediated dilation and impaired NMD in the brachial artery compared to normal-weight adolescents. Similarly, peak responses to acetylcholine and sodium nitroprusside iontophoresis and to local hyperthermia were unaltered, whereas cutaneous blood flow after NMD was lower in the forearm microcirculation of SOA. All plasma measurements were significantly higher in SOA. After the 4-month program, SOA presented a weight reduction of 7.4 ± 3.1%, but neither brachial artery nor microvascular reactivity variables were improved. Significant decreases were detected in plasma leptin, myeloperoxidase, and tissue plasminogen activator.
Conclusions:
Macro- and microvascular endothelial function are preserved in adolescents with severe obesity. Conversely, weight loss does not improve their impaired smooth muscle response to exogenous organic nitrate in both vascular beds, despite reducing plasma markers adversely related to vascular homeostasis. |
| doi_str_mv | 10.1210/jc.2013-3394 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01310171v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1524815881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4821-1310fea9483d367fdc5257177fd486d5177ed1ad75dee1a83026d441303cbac23</originalsourceid><addsrcrecordid>eNptkU1v1DAQhiMEokvhxhn5ggQSKR7biZPjqioUaasivsTN8toT1os33trJVvvvcZSlXPDFY_uZmdfzFsVLoBfAgL7fmgtGgZect-JRsYBWVKWEVj4uFpQyKFvJfp4Vz1LaUgpCVPxpccaEYJwLvijiVdehGRIJHdFk5TpMw9Ej-RzDr6h3JPTkh05m9DqSL6jN4A5uOBLXkxttYiiJ7i25cTk0Lk7Y4HJKfv6KB4zoj-R2jQnJ0gaPyWA_pOfFk077hC9O-3nx_cPVt8vrcnX78dPlclUa0WTdwIF2qFvRcMtr2VlTsUqCzJFoalvlCC1oKyuLCLrhlNVWCOCUm7U2jJ8Xb-e6G-3VPrqdjkcVtFPXy5Wa7ujUAiQcILNvZnYfw92YZ6B2Lqv1XvcYxqSgYqKBqmkm9N2M5j-nFLF7qA1UTY6orVGTI2pyJOOvTpXH9Q7tA_zXggy8PgF5ztp3UffGpX9cw2XNuMycmLn74AeM6bcf7zGqDWo_bBTNS9SyKXNnQXk-ldPNJJfPadjbYKLrcR8xJbUNY-zz-P-v-g-uOrLf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1524815881</pqid></control><display><type>article</type><title>Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Montero, David ; Walther, Guillaume ; Perez-Martin, Antonia ; Mercier, Charles S ; Gayrard, Sandrine ; Vicente-Salar, Nestor ; Sempere-Ortells, José Miguel ; Martinez-Peinado, Pascual ; Roche, Enrique ; Vinet, Agnès</creator><creatorcontrib>Montero, David ; Walther, Guillaume ; Perez-Martin, Antonia ; Mercier, Charles S ; Gayrard, Sandrine ; Vicente-Salar, Nestor ; Sempere-Ortells, José Miguel ; Martinez-Peinado, Pascual ; Roche, Enrique ; Vinet, Agnès</creatorcontrib><description>Context and Objective:
This study aimed to comprehensively assess the macro- and microcirculation of severely obese adolescents (SOA) and normal-weight counterparts and to determine the longitudinal effects of weight loss on vascular function in SOA.
Design, Setting, Participants, and Outcome Measures:
Seventeen SOA (body mass index z-score = 4.22 ± 0.73) and 19 puberty-matched normal-weight counterparts (body mass index z-score = −0.02 ± 1.04) were included. The SOA participated in a 4 month weight loss program. Brachial artery flow-mediated dilation and response to sublingual nitrate (nitrate-mediated dilation [NMD]) were assessed by high-resolution ultrasound. Microvascular reactivity was evaluated by laser Doppler flowmetry in response to NMD, iontophoresis of acetylcholine and sodium nitroprusside, and local hyperthermia. Plasma insulin, leptin, resistin, C-reactive protein, myeloperoxidase, and tissue plasminogen activator were measured.
Results:
At baseline, SOA had similar flow-mediated dilation and impaired NMD in the brachial artery compared to normal-weight adolescents. Similarly, peak responses to acetylcholine and sodium nitroprusside iontophoresis and to local hyperthermia were unaltered, whereas cutaneous blood flow after NMD was lower in the forearm microcirculation of SOA. All plasma measurements were significantly higher in SOA. After the 4-month program, SOA presented a weight reduction of 7.4 ± 3.1%, but neither brachial artery nor microvascular reactivity variables were improved. Significant decreases were detected in plasma leptin, myeloperoxidase, and tissue plasminogen activator.
Conclusions:
Macro- and microvascular endothelial function are preserved in adolescents with severe obesity. Conversely, weight loss does not improve their impaired smooth muscle response to exogenous organic nitrate in both vascular beds, despite reducing plasma markers adversely related to vascular homeostasis.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2013-3394</identifier><identifier>PMID: 24423343</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Human health and pathology ; Humans ; Laser-Doppler Flowmetry ; Life Sciences ; Life Style ; Male ; Medical sciences ; Microcirculation - physiology ; Obesity, Morbid - physiopathology ; Obesity, Morbid - therapy ; Pediatric Obesity - physiopathology ; Pediatric Obesity - therapy ; Risk Reduction Behavior ; Severity of Illness Index ; Vascular Resistance ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Weight Reduction Programs - methods</subject><ispartof>The journal of clinical endocrinology and metabolism, 2014-03, Vol.99 (3), p.1019-1026</ispartof><rights>Copyright © 2014 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4821-1310fea9483d367fdc5257177fd486d5177ed1ad75dee1a83026d441303cbac23</citedby><cites>FETCH-LOGICAL-c4821-1310fea9483d367fdc5257177fd486d5177ed1ad75dee1a83026d441303cbac23</cites><orcidid>0000-0002-8527-7783 ; 0000-0001-7604-8973 ; 0000-0002-6513-630X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28376237$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24423343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01310171$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Montero, David</creatorcontrib><creatorcontrib>Walther, Guillaume</creatorcontrib><creatorcontrib>Perez-Martin, Antonia</creatorcontrib><creatorcontrib>Mercier, Charles S</creatorcontrib><creatorcontrib>Gayrard, Sandrine</creatorcontrib><creatorcontrib>Vicente-Salar, Nestor</creatorcontrib><creatorcontrib>Sempere-Ortells, José Miguel</creatorcontrib><creatorcontrib>Martinez-Peinado, Pascual</creatorcontrib><creatorcontrib>Roche, Enrique</creatorcontrib><creatorcontrib>Vinet, Agnès</creatorcontrib><title>Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context and Objective:
This study aimed to comprehensively assess the macro- and microcirculation of severely obese adolescents (SOA) and normal-weight counterparts and to determine the longitudinal effects of weight loss on vascular function in SOA.
Design, Setting, Participants, and Outcome Measures:
Seventeen SOA (body mass index z-score = 4.22 ± 0.73) and 19 puberty-matched normal-weight counterparts (body mass index z-score = −0.02 ± 1.04) were included. The SOA participated in a 4 month weight loss program. Brachial artery flow-mediated dilation and response to sublingual nitrate (nitrate-mediated dilation [NMD]) were assessed by high-resolution ultrasound. Microvascular reactivity was evaluated by laser Doppler flowmetry in response to NMD, iontophoresis of acetylcholine and sodium nitroprusside, and local hyperthermia. Plasma insulin, leptin, resistin, C-reactive protein, myeloperoxidase, and tissue plasminogen activator were measured.
Results:
At baseline, SOA had similar flow-mediated dilation and impaired NMD in the brachial artery compared to normal-weight adolescents. Similarly, peak responses to acetylcholine and sodium nitroprusside iontophoresis and to local hyperthermia were unaltered, whereas cutaneous blood flow after NMD was lower in the forearm microcirculation of SOA. All plasma measurements were significantly higher in SOA. After the 4-month program, SOA presented a weight reduction of 7.4 ± 3.1%, but neither brachial artery nor microvascular reactivity variables were improved. Significant decreases were detected in plasma leptin, myeloperoxidase, and tissue plasminogen activator.
Conclusions:
Macro- and microvascular endothelial function are preserved in adolescents with severe obesity. Conversely, weight loss does not improve their impaired smooth muscle response to exogenous organic nitrate in both vascular beds, despite reducing plasma markers adversely related to vascular homeostasis.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Laser-Doppler Flowmetry</subject><subject>Life Sciences</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation - physiology</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - therapy</subject><subject>Pediatric Obesity - physiopathology</subject><subject>Pediatric Obesity - therapy</subject><subject>Risk Reduction Behavior</subject><subject>Severity of Illness Index</subject><subject>Vascular Resistance</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Weight Reduction Programs - methods</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1v1DAQhiMEokvhxhn5ggQSKR7biZPjqioUaasivsTN8toT1os33trJVvvvcZSlXPDFY_uZmdfzFsVLoBfAgL7fmgtGgZect-JRsYBWVKWEVj4uFpQyKFvJfp4Vz1LaUgpCVPxpccaEYJwLvijiVdehGRIJHdFk5TpMw9Ej-RzDr6h3JPTkh05m9DqSL6jN4A5uOBLXkxttYiiJ7i25cTk0Lk7Y4HJKfv6KB4zoj-R2jQnJ0gaPyWA_pOfFk077hC9O-3nx_cPVt8vrcnX78dPlclUa0WTdwIF2qFvRcMtr2VlTsUqCzJFoalvlCC1oKyuLCLrhlNVWCOCUm7U2jJ8Xb-e6G-3VPrqdjkcVtFPXy5Wa7ujUAiQcILNvZnYfw92YZ6B2Lqv1XvcYxqSgYqKBqmkm9N2M5j-nFLF7qA1UTY6orVGTI2pyJOOvTpXH9Q7tA_zXggy8PgF5ztp3UffGpX9cw2XNuMycmLn74AeM6bcf7zGqDWo_bBTNS9SyKXNnQXk-ldPNJJfPadjbYKLrcR8xJbUNY-zz-P-v-g-uOrLf</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Montero, David</creator><creator>Walther, Guillaume</creator><creator>Perez-Martin, Antonia</creator><creator>Mercier, Charles S</creator><creator>Gayrard, Sandrine</creator><creator>Vicente-Salar, Nestor</creator><creator>Sempere-Ortells, José Miguel</creator><creator>Martinez-Peinado, Pascual</creator><creator>Roche, Enrique</creator><creator>Vinet, Agnès</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8527-7783</orcidid><orcidid>https://orcid.org/0000-0001-7604-8973</orcidid><orcidid>https://orcid.org/0000-0002-6513-630X</orcidid></search><sort><creationdate>201403</creationdate><title>Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents</title><author>Montero, David ; Walther, Guillaume ; Perez-Martin, Antonia ; Mercier, Charles S ; Gayrard, Sandrine ; Vicente-Salar, Nestor ; Sempere-Ortells, José Miguel ; Martinez-Peinado, Pascual ; Roche, Enrique ; Vinet, Agnès</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4821-1310fea9483d367fdc5257177fd486d5177ed1ad75dee1a83026d441303cbac23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Laser-Doppler Flowmetry</topic><topic>Life Sciences</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microcirculation - physiology</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - therapy</topic><topic>Pediatric Obesity - physiopathology</topic><topic>Pediatric Obesity - therapy</topic><topic>Risk Reduction Behavior</topic><topic>Severity of Illness Index</topic><topic>Vascular Resistance</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Weight Reduction Programs - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montero, David</creatorcontrib><creatorcontrib>Walther, Guillaume</creatorcontrib><creatorcontrib>Perez-Martin, Antonia</creatorcontrib><creatorcontrib>Mercier, Charles S</creatorcontrib><creatorcontrib>Gayrard, Sandrine</creatorcontrib><creatorcontrib>Vicente-Salar, Nestor</creatorcontrib><creatorcontrib>Sempere-Ortells, José Miguel</creatorcontrib><creatorcontrib>Martinez-Peinado, Pascual</creatorcontrib><creatorcontrib>Roche, Enrique</creatorcontrib><creatorcontrib>Vinet, Agnès</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montero, David</au><au>Walther, Guillaume</au><au>Perez-Martin, Antonia</au><au>Mercier, Charles S</au><au>Gayrard, Sandrine</au><au>Vicente-Salar, Nestor</au><au>Sempere-Ortells, José Miguel</au><au>Martinez-Peinado, Pascual</au><au>Roche, Enrique</au><au>Vinet, Agnès</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2014-03</date><risdate>2014</risdate><volume>99</volume><issue>3</issue><spage>1019</spage><epage>1026</epage><pages>1019-1026</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context and Objective:
This study aimed to comprehensively assess the macro- and microcirculation of severely obese adolescents (SOA) and normal-weight counterparts and to determine the longitudinal effects of weight loss on vascular function in SOA.
Design, Setting, Participants, and Outcome Measures:
Seventeen SOA (body mass index z-score = 4.22 ± 0.73) and 19 puberty-matched normal-weight counterparts (body mass index z-score = −0.02 ± 1.04) were included. The SOA participated in a 4 month weight loss program. Brachial artery flow-mediated dilation and response to sublingual nitrate (nitrate-mediated dilation [NMD]) were assessed by high-resolution ultrasound. Microvascular reactivity was evaluated by laser Doppler flowmetry in response to NMD, iontophoresis of acetylcholine and sodium nitroprusside, and local hyperthermia. Plasma insulin, leptin, resistin, C-reactive protein, myeloperoxidase, and tissue plasminogen activator were measured.
Results:
At baseline, SOA had similar flow-mediated dilation and impaired NMD in the brachial artery compared to normal-weight adolescents. Similarly, peak responses to acetylcholine and sodium nitroprusside iontophoresis and to local hyperthermia were unaltered, whereas cutaneous blood flow after NMD was lower in the forearm microcirculation of SOA. All plasma measurements were significantly higher in SOA. After the 4-month program, SOA presented a weight reduction of 7.4 ± 3.1%, but neither brachial artery nor microvascular reactivity variables were improved. Significant decreases were detected in plasma leptin, myeloperoxidase, and tissue plasminogen activator.
Conclusions:
Macro- and microvascular endothelial function are preserved in adolescents with severe obesity. Conversely, weight loss does not improve their impaired smooth muscle response to exogenous organic nitrate in both vascular beds, despite reducing plasma markers adversely related to vascular homeostasis.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>24423343</pmid><doi>10.1210/jc.2013-3394</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8527-7783</orcidid><orcidid>https://orcid.org/0000-0001-7604-8973</orcidid><orcidid>https://orcid.org/0000-0002-6513-630X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2014-03, Vol.99 (3), p.1019-1026 |
| issn | 0021-972X 1945-7197 |
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| recordid | cdi_hal_primary_oai_HAL_hal_01310171v1 |
| source | MEDLINE; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Biological and medical sciences Child Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Human health and pathology Humans Laser-Doppler Flowmetry Life Sciences Life Style Male Medical sciences Microcirculation - physiology Obesity, Morbid - physiopathology Obesity, Morbid - therapy Pediatric Obesity - physiopathology Pediatric Obesity - therapy Risk Reduction Behavior Severity of Illness Index Vascular Resistance Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Weight Reduction Programs - methods |
| title | Effects of a Lifestyle Program on Vascular Reactivity in Macro- and Microcirculation in Severely Obese Adolescents |
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